Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
| Location | 1231768..1232390 | Replicon | chromosome |
| Accession | NZ_CP054794 | ||
| Organism | Pseudomonas aeruginosa strain A0002 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | HUK78_RS05780 | Protein ID | WP_023910260.1 |
| Coordinates | 1231768..1232082 (+) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HUK78_RS05785 | Protein ID | WP_023910258.1 |
| Coordinates | 1232085..1232390 (+) | Length | 102 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUK78_RS05755 (HUK78_05755) | 1227901..1228857 | + | 957 | WP_223716503.1 | site-specific integrase | - |
| HUK78_RS05760 (HUK78_05760) | 1228926..1229237 | + | 312 | WP_031631670.1 | outer membrane protein assembly factor BamE | - |
| HUK78_RS05765 (HUK78_05765) | 1229369..1230019 | + | 651 | WP_235175986.1 | BRCT domain-containing protein | - |
| HUK78_RS05770 (HUK78_05770) | 1230161..1230718 | + | 558 | WP_049264286.1 | Panacea domain-containing protein | - |
| HUK78_RS05775 (HUK78_05775) | 1230715..1231134 | + | 420 | WP_049264287.1 | hypothetical protein | - |
| HUK78_RS05780 (HUK78_05780) | 1231768..1232082 | + | 315 | WP_023910260.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HUK78_RS05785 (HUK78_05785) | 1232085..1232390 | + | 306 | WP_023910258.1 | helix-turn-helix domain-containing protein | Antitoxin |
| HUK78_RS05790 (HUK78_05790) | 1232451..1232753 | - | 303 | WP_073665794.1 | hypothetical protein | - |
| HUK78_RS05795 (HUK78_05795) | 1232750..1233463 | - | 714 | WP_235175899.1 | hypothetical protein | - |
| HUK78_RS05800 (HUK78_05800) | 1233460..1233651 | - | 192 | WP_021205282.1 | hypothetical protein | - |
| HUK78_RS05805 (HUK78_05805) | 1233907..1234335 | - | 429 | WP_019486521.1 | hypothetical protein | - |
| HUK78_RS05810 (HUK78_05810) | 1234380..1235216 | - | 837 | WP_003085692.1 | prohibitin family protein | - |
| HUK78_RS05815 (HUK78_05815) | 1235213..1235467 | - | 255 | WP_003085694.1 | hypothetical protein | - |
| HUK78_RS05820 (HUK78_05820) | 1235567..1235800 | - | 234 | WP_021205288.1 | hypothetical protein | - |
| HUK78_RS05825 (HUK78_05825) | 1235803..1236183 | - | 381 | WP_235175900.1 | LuxR C-terminal-related transcriptional regulator | - |
| HUK78_RS05830 (HUK78_05830) | 1236297..1237067 | - | 771 | WP_121353306.1 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1227901..1272351 | 44450 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11776.54 Da Isoelectric Point: 9.4385
>T160480 WP_023910260.1 NZ_CP054794:1231768-1232082 [Pseudomonas aeruginosa]
MIFIETPVFTKRILALVDDETYRKLQEDLTLHPDAGVVIEGTGGVRKIRIAANGHGKRGGARVIYYHFTSASQIAFLLAY
DKASQEDLTADQKKMLRQIVENWR
MIFIETPVFTKRILALVDDETYRKLQEDLTLHPDAGVVIEGTGGVRKIRIAANGHGKRGGARVIYYHFTSASQIAFLLAY
DKASQEDLTADQKKMLRQIVENWR
Download Length: 315 bp
>T160480 NZ_CP054794:1231768-1232082 [Pseudomonas aeruginosa]
ATGATCTTCATCGAAACGCCAGTCTTCACGAAGCGGATTCTCGCGCTGGTAGACGACGAGACCTATCGCAAGCTTCAGGA
AGACCTAACGCTCCACCCGGACGCCGGAGTGGTCATTGAAGGCACGGGTGGCGTGCGCAAGATTCGCATTGCTGCCAATG
GCCACGGGAAAAGAGGCGGCGCCCGGGTCATCTACTACCATTTCACATCCGCCTCTCAAATTGCATTCCTGCTGGCCTAT
GACAAAGCGTCGCAGGAAGATCTGACTGCCGATCAGAAAAAGATGCTTCGGCAGATCGTTGAGAACTGGAGATAG
ATGATCTTCATCGAAACGCCAGTCTTCACGAAGCGGATTCTCGCGCTGGTAGACGACGAGACCTATCGCAAGCTTCAGGA
AGACCTAACGCTCCACCCGGACGCCGGAGTGGTCATTGAAGGCACGGGTGGCGTGCGCAAGATTCGCATTGCTGCCAATG
GCCACGGGAAAAGAGGCGGCGCCCGGGTCATCTACTACCATTTCACATCCGCCTCTCAAATTGCATTCCTGCTGGCCTAT
GACAAAGCGTCGCAGGAAGATCTGACTGCCGATCAGAAAAAGATGCTTCGGCAGATCGTTGAGAACTGGAGATAG
Antitoxin
Download Length: 102 a.a. Molecular weight: 11316.84 Da Isoelectric Point: 7.2077
>AT160480 WP_023910258.1 NZ_CP054794:1232085-1232390 [Pseudomonas aeruginosa]
MDKELFAELVESVTQMDEIVRGERQPSREFHVDAVKVKEIRRATGLSQAKFARKIDVAVGTLRNWEQGRRDPEGPARALL
RAIDNDPVHVLAALNGGPRES
MDKELFAELVESVTQMDEIVRGERQPSREFHVDAVKVKEIRRATGLSQAKFARKIDVAVGTLRNWEQGRRDPEGPARALL
RAIDNDPVHVLAALNGGPRES
Download Length: 306 bp
>AT160480 NZ_CP054794:1232085-1232390 [Pseudomonas aeruginosa]
ATGGACAAAGAACTCTTCGCTGAACTGGTCGAAAGCGTGACCCAGATGGACGAGATCGTGCGTGGCGAACGTCAACCTTC
CCGCGAGTTCCACGTCGACGCGGTGAAGGTCAAGGAAATCCGCCGCGCTACTGGCCTGTCCCAGGCCAAATTCGCCCGAA
AGATCGATGTTGCTGTTGGAACCCTGCGCAATTGGGAGCAAGGGCGCCGCGATCCCGAGGGGCCTGCCCGCGCCCTGCTC
CGGGCCATTGACAATGATCCGGTTCATGTTCTGGCTGCCCTGAATGGTGGCCCGCGAGAAAGCTAA
ATGGACAAAGAACTCTTCGCTGAACTGGTCGAAAGCGTGACCCAGATGGACGAGATCGTGCGTGGCGAACGTCAACCTTC
CCGCGAGTTCCACGTCGACGCGGTGAAGGTCAAGGAAATCCGCCGCGCTACTGGCCTGTCCCAGGCCAAATTCGCCCGAA
AGATCGATGTTGCTGTTGGAACCCTGCGCAATTGGGAGCAAGGGCGCCGCGATCCCGAGGGGCCTGCCCGCGCCCTGCTC
CGGGCCATTGACAATGATCCGGTTCATGTTCTGGCTGCCCTGAATGGTGGCCCGCGAGAAAGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|