160389

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 35049..35318 Replicon plasmid pKP20194a2-p2
Accession NZ_CP054776
Organism Klebsiella pneumoniae strain KP20194a2

Toxin (Protein)


Gene name hok Uniprot ID P11895
Locus tag HUR99_RS28150 Protein ID WP_001312861.1
Coordinates 35160..35318 (+) Length 53 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 35049..35114 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUR99_RS28125 30759..31286 + 528 WP_000290834.1 single-stranded DNA-binding protein -
HUR99_RS28130 31344..31577 + 234 WP_000006003.1 DUF905 family protein -
HUR99_RS28135 31638..33661 + 2024 Protein_42 ParB/RepB/Spo0J family partition protein -
HUR99_RS28140 33730..34164 + 435 WP_000845953.1 conjugation system SOS inhibitor PsiB -
HUR99_RS28145 34161..34880 + 720 WP_001276217.1 plasmid SOS inhibition protein A -
- 34892..35116 + 225 NuclAT_0 - -
- 34892..35116 + 225 NuclAT_0 - -
- 34892..35116 + 225 NuclAT_0 - -
- 34892..35116 + 225 NuclAT_0 - -
- 35049..35114 + 66 - - Antitoxin
HUR99_RS28150 35160..35318 + 159 WP_001312861.1 type I toxin-antitoxin system Hok family toxin Toxin
HUR99_RS28155 35556..35933 - 378 Protein_46 hypothetical protein -
HUR99_RS28160 36233..36529 + 297 WP_001272251.1 hypothetical protein -
HUR99_RS28165 36640..37461 + 822 WP_001234445.1 DUF945 domain-containing protein -
HUR99_RS28170 37758..38405 - 648 WP_015059008.1 transglycosylase SLT domain-containing protein -
HUR99_RS28175 38682..39065 + 384 WP_000124981.1 relaxosome protein TraM -
HUR99_RS28180 39346..40050 + 705 WP_001067855.1 IS6-like element IS26 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaCTX-M-65 / blaTEM-1B / rmtB / blaSHV-12 / blaKPC-2 - 1..133772 133772


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-48)


Sequences


Toxin        


Download         Length: 53 a.a.        Molecular weight: 6082.32 Da        Isoelectric Point: 9.2584

>T160389 WP_001312861.1 NZ_CP054776:35160-35318 [Klebsiella pneumoniae]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 159 bp

>T160389 NZ_CP070482:4127121-4127435 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 66 bp

>AT160389 NZ_CP054776:35049-35114 [Klebsiella pneumoniae]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB P11895


Antitoxin

Download structure file

References