Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 41511..42238 | Replicon | plasmid pKP20194e-p1 |
Accession | NZ_CP054727 | ||
Organism | Klebsiella pneumoniae strain KP20194e |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A7W3D9W1 |
Locus tag | HUS07_RS27070 | Protein ID | WP_011251285.1 |
Coordinates | 41927..42238 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | HUS07_RS27065 | Protein ID | WP_011251286.1 |
Coordinates | 41511..41930 (-) | Length | 140 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HUS07_RS27035 | 36679..37149 | - | 471 | WP_048333570.1 | hypothetical protein | - |
HUS07_RS27040 | 37342..38097 | - | 756 | Protein_38 | hypothetical protein | - |
HUS07_RS27045 | 38693..39136 | + | 444 | WP_048333569.1 | hypothetical protein | - |
HUS07_RS27050 | 39157..39945 | + | 789 | WP_040217257.1 | hypothetical protein | - |
HUS07_RS27055 | 39959..40294 | + | 336 | Protein_41 | conjugal transfer protein TraI | - |
HUS07_RS27060 | 40396..41364 | - | 969 | WP_074428168.1 | IS5 family transposase | - |
HUS07_RS27065 | 41511..41930 | - | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
HUS07_RS27070 | 41927..42238 | - | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
HUS07_RS27075 | 42443..42901 | - | 459 | Protein_45 | DDE-type integrase/transposase/recombinase | - |
HUS07_RS27080 | 43015..43712 | + | 698 | Protein_46 | IS1 family transposase | - |
HUS07_RS27085 | 43728..44447 | - | 720 | Protein_47 | aldo/keto reductase | - |
HUS07_RS27090 | 44444..44923 | - | 480 | WP_004212799.1 | hypothetical protein | - |
HUS07_RS27095 | 44920..45105 | - | 186 | WP_045145446.1 | hypothetical protein | - |
HUS07_RS27100 | 45109..45225 | + | 117 | Protein_50 | Tn3 family transposase | - |
HUS07_RS27105 | 45508..45738 | - | 231 | WP_011154571.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | - | iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..195027 | 195027 | |
- | inside | IScluster/Tn | - | - | 22688..43712 | 21024 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T160151 WP_011251285.1 NZ_CP054727:c42238-41927 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
>T160151 NZ_CP070327:2323591-2323767 [Ferrovum myxofaciens]
ATGAACTCCAAGCAGATGAAGAAATGGCTAGAGCAACAGGGCGCGACTTTCCAGCCCGGTAAAGGCTCGCACCTGAAGGT
GTTTCTGAATGGCAAGCAGTCTTCACTCCCCATGCACGGTACCGCCGAACTTGGTAAAGGGCTGGAAGCCGCGATCAAAC
GACAGCTTGGTTTGTGA
ATGAACTCCAAGCAGATGAAGAAATGGCTAGAGCAACAGGGCGCGACTTTCCAGCCCGGTAAAGGCTCGCACCTGAAGGT
GTTTCTGAATGGCAAGCAGTCTTCACTCCCCATGCACGGTACCGCCGAACTTGGTAAAGGGCTGGAAGCCGCGATCAAAC
GACAGCTTGGTTTGTGA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT160151 WP_011251286.1 NZ_CP054727:c41930-41511 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT160151 NZ_CP070327:2323781-2324200 [Ferrovum myxofaciens]
ATGATGTTCGACTACCCCGTGACCTTGACCCCCGATGACGGCACCATGCTGGTTACATTTGCCGATGTGCCCGAAGCCAT
CACCTTCGGTGCCGATGAGGATGAAGCCCTGCTGAACGCAATCGATGCGCTGGAAACGGGCTTGTCGTTTTATGTCGATG
CTCGCAAATCGCTACCCGTCGCCAGTCAGCCGGCGGCTGGACAAAAGACCGTGCGGCCATCGGCGCTGGAATGTGCCAAG
CTGGGCATTTACCAAGCGATGACCGATCAGGGAATCAAGAAGGCGGAACTCGCCCGCCGCTTGGGATGGCATATGCCGCA
AGTTGATCGCTTGTTCGATTTGCGTCATGCTTCAAAACTCGACCAGATCGAGGCTGCTGCCAACGTGCTCGGCAAACACG
TTTACGTGCAGATTGCCTGA
ATGATGTTCGACTACCCCGTGACCTTGACCCCCGATGACGGCACCATGCTGGTTACATTTGCCGATGTGCCCGAAGCCAT
CACCTTCGGTGCCGATGAGGATGAAGCCCTGCTGAACGCAATCGATGCGCTGGAAACGGGCTTGTCGTTTTATGTCGATG
CTCGCAAATCGCTACCCGTCGCCAGTCAGCCGGCGGCTGGACAAAAGACCGTGCGGCCATCGGCGCTGGAATGTGCCAAG
CTGGGCATTTACCAAGCGATGACCGATCAGGGAATCAAGAAGGCGGAACTCGCCCGCCGCTTGGGATGGCATATGCCGCA
AGTTGATCGCTTGTTCGATTTGCGTCATGCTTCAAAACTCGACCAGATCGAGGCTGCTGCCAACGTGCTCGGCAAACACG
TTTACGTGCAGATTGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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