Detailed information of TA system TA160081

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 5454905..5455517
• Replicon: chromosome
• Accession: NZ_CP054698
• Organism: Nostoc edaphicum CCNP1411

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: HUN01_RS25705
• Protein ID: WP_181928545.1
• Coordinates: 5455224..5455517 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HUN01_RS25700
• Protein ID: WP_181928544.1
• Coordinates: 5454905..5455210 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUN01_RS25685	5450866..5451771	-	906	WP_181932822.1	TatD family hydrolase	-
HUN01_RS25690	5451957..5452838	-	882	WP_181928542.1	EboA family metabolite traffic protein	-
HUN01_RS25695	5453312..5454514	+	1203	WP_181928543.1	3-dehydroquinate synthase	-
HUN01_RS25700	5454905..5455210	-	306	WP_181928544.1	HigA family addiction module antidote protein	Antitoxin
HUN01_RS25705	5455224..5455517	-	294	WP_181928545.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HUN01_RS25710	5455733..5456431	-	699	WP_181928546.1	YdcF family protein	-
HUN01_RS25715	5456743..5458083	+	1341	WP_181928547.1	S41 family peptidase	-
HUN01_RS25720	5458351..5459319	+	969	WP_181928548.1	glycosyltransferase	-
HUN01_RS25725	5459505..5459714	+	210	Protein_4534	DUF29 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-71)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11253.76 Da
• Isoelectric Point: 5.7129

>T160081 WP_181928545.1 NZ_CP054698:c5455517-5455224 [Nostoc edaphicum CCNP1411]
MIVSFKDQGTEDIFDGNDSKEARKQCPIYCWEIARRKLDQLNAALSLDDIKVPPGNRLEVLKGDRKGQHSIRINDQYRIC
FIWTLQGTSEVEIVDYH

Nucleotide

• Length: 294 bp

>T160081 NZ_CP070290:1990180-1990283 [Escherichia albertii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAAC
AGGAATCGTTTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11977.77 Da
• Isoelectric Point: 8.4580

>AT160081 WP_181928544.1 NZ_CP054698:c5455210-5454905 [Nostoc edaphicum CCNP1411]
MRVPKYRPPSHPGEILLKDFLDPMGITQRELADALHVPYQRINELVNQKRGITPSTAIRLSKFFGNSSEFWLNLQQNWEL
YYVLKEEEEELKSILQFRTTK

Nucleotide

• Length: 306 bp

>AT160081 NZ_CP070290:c1990285-1990053 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT