Detailed information of TA system TA160064

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3751883..3752105
• Replicon: chromosome
• Accession: NZ_CP054665
• Organism: Escherichia coli strain IGC_EcoliInv_1.1

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: HUR94_RS18475
• Protein ID: WP_000141634.1
• Coordinates: 3751883..3751990 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3752039..3752105 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUR94_RS18450	3747136..3747864	-	729	WP_011310329.1	cellulose biosynthesis protein BcsQ	-
HUR94_RS18455	3747900..3748088	-	189	WP_001063318.1	cellulose biosynthesis protein BcsR	-
HUR94_RS18460	3748361..3749932	+	1572	WP_001204931.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
HUR94_RS18465	3749929..3750120	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
HUR94_RS18470	3750117..3751796	+	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
HUR94_RS18475	3751883..3751990	-	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
-	3752039..3752105	+	67	-	-	Antitoxin
HUR94_RS18480	3752466..3753737	+	1272	WP_001295225.1	aromatic amino acid transport family protein	-
HUR94_RS18485	3753767..3754771	-	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
HUR94_RS18490	3754768..3755751	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
HUR94_RS18495	3755762..3756664	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T160064 WP_000141634.1 NZ_CP054665:c3751990-3751883 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T160064 NZ_CP070287:2388618-2388896 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT160064 NZ_CP054665:3752039-3752105 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin