160063

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3380254..3380947 Replicon chromosome
Accession NZ_CP054665
Organism Escherichia coli strain IGC_EcoliInv_1.1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HUR94_RS16670 Protein ID WP_000415584.1
Coordinates 3380254..3380550 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HUR94_RS16675 Protein ID WP_000650107.1
Coordinates 3380552..3380947 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUR94_RS16635 (3375342) 3375342..3375656 - 315 WP_000958598.1 putative quinol monooxygenase -
HUR94_RS16640 (3375687) 3375687..3376268 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HUR94_RS16645 (3376587) 3376587..3376919 + 333 WP_000917684.1 DUF2645 family protein -
HUR94_RS16650 (3376965) 3376965..3378314 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
HUR94_RS16655 (3378311) 3378311..3378970 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
HUR94_RS16660 (3379122) 3379122..3379514 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HUR94_RS16665 (3379567) 3379567..3380049 + 483 WP_000183505.1 GyrI-like domain-containing protein -
HUR94_RS16670 (3380254) 3380254..3380550 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HUR94_RS16675 (3380552) 3380552..3380947 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HUR94_RS16680 (3381080) 3381080..3382687 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HUR94_RS16685 (3382825) 3382825..3385083 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T160063 WP_000415584.1 NZ_CP054665:3380254-3380550 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T160063 NZ_CP070287:2081380-2081482 [Escherichia albertii]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAACA
GGAATCGTTTTCGGTCTCTTTTT

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT160063 WP_000650107.1 NZ_CP054665:3380552-3380947 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT160063 NZ_CP070287:c2081484-2081252 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References