Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 2093252..2093754 | Replicon | chromosome |
| Accession | NZ_CP054665 | ||
| Organism | Escherichia coli strain IGC_EcoliInv_1.1 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | HUR94_RS10510 | Protein ID | WP_000767829.1 |
| Coordinates | 2093252..2093506 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | HUR94_RS10515 | Protein ID | WP_001259255.1 |
| Coordinates | 2093503..2093754 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUR94_RS10480 (2088267) | 2088267..2088494 | - | 228 | WP_000234896.1 | sulfurtransferase TusA | - |
| HUR94_RS10485 (2088508) | 2088508..2089566 | - | 1059 | WP_000492339.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| HUR94_RS10490 (2089745) | 2089745..2091103 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| HUR94_RS10495 (2091093) | 2091093..2091155 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| HUR94_RS10500 (2091370) | 2091370..2092299 | - | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| HUR94_RS10505 (2092345) | 2092345..2093169 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| HUR94_RS10510 (2093252) | 2093252..2093506 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| HUR94_RS10515 (2093503) | 2093503..2093754 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| HUR94_RS10520 (2094037) | 2094037..2094087 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| HUR94_RS10525 (2094233) | 2094233..2095132 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| HUR94_RS10530 (2095138) | 2095138..2096442 | + | 1305 | WP_000009594.1 | histidinol dehydrogenase | - |
| HUR94_RS10535 (2096439) | 2096439..2097509 | + | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
| HUR94_RS10540 (2097509) | 2097509..2098576 | + | 1068 | WP_000080105.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T160056 WP_000767829.1 NZ_CP054665:c2093506-2093252 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T160056 NZ_CP070286:114801-115106 [Escherichia albertii]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCTTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCTTGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGTCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGGGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCTTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCTTGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGTCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGGGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT160056 WP_001259255.1 NZ_CP054665:c2093754-2093503 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT160056 NZ_CP070286:114581-114799 [Escherichia albertii]
ATGAAGCAGCGCATTACAGTTACCGTCGACAGTGACAGCTATCAGTTGCTCAAAGCATATGATGTCAATATCTCCGGTCT
GGTAAGTACAACCATGCAGAACGAAGCCCGTCGTCTGCGTGCTGAACGCTGGAAAGCAGAAAATCAGGAAGGGATGGTTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGAACTGGTGA
ATGAAGCAGCGCATTACAGTTACCGTCGACAGTGACAGCTATCAGTTGCTCAAAGCATATGATGTCAATATCTCCGGTCT
GGTAAGTACAACCATGCAGAACGAAGCCCGTCGTCTGCGTGCTGAACGCTGGAAAGCAGAAAATCAGGAAGGGATGGTTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGAACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|