Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2398645..2399272 Replicon chromosome
Accession NZ_CP054626
Organism Cupriavidus gilardii strain FDAARGOS_639

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FOB47_RS20955 Protein ID WP_082371643.1
Coordinates 2398645..2398926 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FOB47_RS20960 Protein ID WP_174782522.1
Coordinates 2398958..2399272 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB47_RS20930 2393962..2394639 + 678 WP_174782017.1 ATP-binding cassette domain-containing protein -
FOB47_RS20935 2394736..2395554 - 819 WP_053822305.1 TOBE domain-containing protein -
FOB47_RS20940 2395736..2396872 + 1137 WP_174782018.1 HPP family protein -
FOB47_RS20945 2397186..2397881 + 696 WP_174782019.1 transglycosylase domain-containing protein -
FOB47_RS20950 2398034..2398501 + 468 WP_053822307.1 MgtC/SapB family protein -
FOB47_RS20955 2398645..2398926 + 282 WP_082371643.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOB47_RS20960 2398958..2399272 + 315 WP_174782522.1 HigA family addiction module antidote protein Antitoxin
FOB47_RS20965 2399329..2399550 - 222 WP_053822308.1 formate dehydrogenase subunit delta -
FOB47_RS20970 2399553..2400359 - 807 WP_174782523.1 formate dehydrogenase accessory sulfurtransferase FdhD -
FOB47_RS20975 2400463..2403345 - 2883 WP_174782020.1 formate dehydrogenase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - htpB / ugd / sodB 2254857..2474150 219293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(22-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-87)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10702.35 Da        Isoelectric Point: 8.7701

>T159994 WP_082371643.1 NZ_CP054626:2398645-2398926 [Cupriavidus gilardii]
MIQSFRCMDTRALFEGKRVARFTNIHAVAERKLQMLESATTLASLMAPPGNRLEILSGNRRGQYSIRVNAQWRICFLWTS
EGPQCVEIVDYHD

Download         Length: 282 bp

>T159994 NZ_CP070232:c610010-609546 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11468.03 Da        Isoelectric Point: 5.6343

>AT159994 WP_174782522.1 NZ_CP054626:2398958-2399272 [Cupriavidus gilardii]
MARFHNGMRPVHPGEILREEYLVPLDLSIAELAKELHVDTAQIDAIVRGNAGVTSEIALRLARYFGGDAETWLNLQQAYD
LKTAEQQVGDAIRSEVAPRKAKAA

Download         Length: 315 bp

>AT159994 NZ_CP070232:c610345-610010 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References