Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 4269..4783 Replicon plasmid unnamed6
Accession NZ_CP054605
Organism Sulfitobacter pseudonitzschiae strain H46

Toxin (Protein)


Gene name yoeB Uniprot ID A0A073IWB6
Locus tag HT745_RS22255 Protein ID WP_037931654.1
Coordinates 4517..4783 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A073IVW4
Locus tag HT745_RS22250 Protein ID WP_037931651.1
Coordinates 4269..4520 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HT745_RS22215 548..1197 - 650 Protein_1 N-6 DNA methylase -
HT745_RS22220 1287..1502 - 216 WP_037931637.1 hypothetical protein -
HT745_RS22225 1489..1751 - 263 Protein_3 BrnT family toxin -
HT745_RS22230 1909..2130 - 222 WP_174861796.1 WGR domain-containing protein -
HT745_RS22235 2176..2454 - 279 WP_174861794.1 tyrosine-type recombinase/integrase -
HT745_RS22240 2384..2806 - 423 WP_174861795.1 tyrosine-type recombinase/integrase -
HT745_RS22245 2973..4157 - 1185 WP_037931648.1 hypothetical protein -
HT745_RS22250 4269..4520 + 252 WP_037931651.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HT745_RS22255 4517..4783 + 267 WP_037931654.1 Txe/YoeB family addiction module toxin Toxin
HT745_RS22260 4844..5662 - 819 WP_037931655.1 GIY-YIG nuclease family protein -
HT745_RS22265 5763..6227 - 465 WP_037931690.1 hypothetical protein -
HT745_RS22270 6373..7059 - 687 WP_037931693.1 DNA-protecting protein DprA -
HT745_RS22275 7166..7465 - 300 WP_132953151.1 hypothetical protein -
HT745_RS22280 7410..8081 - 672 WP_037931658.1 AAA family ATPase -
HT745_RS22285 8141..9169 - 1029 WP_037931660.1 replication initiator protein A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..23927 23927


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10410.74 Da        Isoelectric Point: 9.4821

>T159973 WP_037931654.1 NZ_CP054605:4517-4783 [Sulfitobacter pseudonitzschiae]
VKLVFSDQAWEDYQYWVSTNDKVRDRINELIKQCKRTPFKGTGKPEPLKGDLTGWWSRRISQEDRMVYRVSGTGDGQSLE
IAQLRFHY

Download         Length: 267 bp

>T159973 NZ_CP070229:1649911-1650129 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9209.44 Da        Isoelectric Point: 5.6939

>AT159973 WP_037931651.1 NZ_CP054605:4269-4520 [Sulfitobacter pseudonitzschiae]
MDVMTYSDARAQLKGVMDRAIHDKQEIVVTRKKGESVVVVSLETWNAVNETLHLLSTPKNASRLRASIAQLDAGTGEERE
LTE

Download         Length: 252 bp

>AT159973 NZ_CP070229:1649511-1649885 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A073IWB6

Antitoxin

Source ID Structure
AlphaFold DB A0A073IVW4

References