Detailed information of TA system TA159924

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 7617..8141
• Replicon: plasmid pUTI-050-3
• Accession: NZ_CP054578
• Organism: Staphylococcus saprophyticus strain UTI-050

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HSZ50_RS13330
• Protein ID: WP_069822312.1
• Coordinates: 7617..7883 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HSZ50_RS13335
• Protein ID: WP_069822313.1
• Coordinates: 7884..8141 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSZ50_RS13315	3595..4014	+	420	WP_040029815.1	hypothetical protein	-
HSZ50_RS13320	4185..4628	-	444	WP_169926875.1	IS200/IS605 family transposase	-
HSZ50_RS13325	4708..5850	+	1143	WP_040029817.1	transposase	-
HSZ50_RS13330	7617..7883	-	267	WP_069822312.1	Txe/YoeB family addiction module toxin	Toxin
HSZ50_RS13335	7884..8141	-	258	WP_069822313.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HSZ50_RS13340	8348..8449	+	102	WP_002446825.1	type I toxin-antitoxin system Fst family toxin	-
HSZ50_RS13345	8731..10191	-	1461	WP_069825656.1	glucose-6-phosphate dehydrogenase	-
HSZ50_RS13350	10255..11661	-	1407	WP_069825657.1	NADP-dependent phosphogluconate dehydrogenase	-
HSZ50_RS13355	11693..13024	-	1332	WP_069825658.1	glucose-6-phosphate isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..28716	28716

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10588.99 Da
• Isoelectric Point: 9.2992

>T159924 WP_069822312.1 NZ_CP054578:c7883-7617 [Staphylococcus saprophyticus]
MDNYSISIKNSAKSDLKKIKQSQLKTQFLKIVDTLKEDPYFPSQSFEKLQPKHLERYSRRINHQHRVVYTVDEDDKEVFI
LSAWSHYE

Nucleotide

• Length: 267 bp

>T159924 NZ_CP070171:c107877-107572 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9880.86 Da
• Isoelectric Point: 4.2797

>AT159924 WP_069822313.1 NZ_CP054578:c8141-7884 [Staphylococcus saprophyticus]
MNIKTPTNARKEFYELLKQVNDSHEPVIISSSKSENNAVIISQKDWDSIQETLYLETTGTMDKVREREKDNSGYTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT159924 NZ_CP070171:c108097-107879 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA