Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 14942..15460 Replicon plasmid pUTI-050-2
Accession NZ_CP054577
Organism Staphylococcus saprophyticus strain UTI-050

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HSZ50_RS13225 Protein ID WP_011304050.1
Coordinates 14942..15211 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HSZ50_RS13230 Protein ID WP_011304051.1
Coordinates 15212..15460 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSZ50_RS13205 11139..12404 + 1266 WP_011304047.1 replication initiator protein A -
HSZ50_RS13210 12370..13047 + 678 WP_103314606.1 transposase -
HSZ50_RS13215 13065..13343 + 279 WP_002508705.1 hypothetical protein -
HSZ50_RS13220 14045..14719 + 675 WP_174605061.1 IS6 family transposase -
HSZ50_RS13225 14942..15211 - 270 WP_011304050.1 Txe/YoeB family addiction module toxin Toxin
HSZ50_RS13230 15212..15460 - 249 WP_011304051.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HSZ50_RS13235 15768..16766 - 999 WP_041785008.1 ThiF family adenylyltransferase -
HSZ50_RS13240 16766..17533 - 768 WP_011304054.1 thiazole synthase -
HSZ50_RS13245 17535..17735 - 201 WP_011304055.1 sulfur carrier protein ThiS -
HSZ50_RS13250 17725..18837 - 1113 WP_011304056.1 FAD-binding oxidoreductase -
HSZ50_RS13255 18830..19414 - 585 WP_041785010.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..29715 29715
- flank IS/Tn - - 14045..14719 674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-73)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10361.96 Da        Isoelectric Point: 10.1510

>T159923 WP_011304050.1 NZ_CP054577:c15211-14942 [Staphylococcus saprophyticus]
MAKLNITFSPQAFEDYEYFQLKDRPMVKRINKLLKSINRDGALGGIGKPEKLVGSLSGYYSRRINQEHRLVYTVNDTSIM
VASCRYHYR

Download         Length: 270 bp

>T159923 NZ_CP070171:c55296-55162 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9483.53 Da        Isoelectric Point: 4.3525

>AT159923 WP_011304051.1 NZ_CP054577:c15460-15212 [Staphylococcus saprophyticus]
VTVKNYTFVRDNFRDMINKVNDDSDTITITTKDRNAVLMSEDDYDAIMETLYLQQNPSNAKHLAESIENLERGNVKSKEI
EI

Download         Length: 249 bp

>AT159923 NZ_CP070171:55341-55401 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References