Detailed information of TA system TA159920

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-sprA1AS/-
• Location: 35133..35281
• Replicon: plasmid pUTI-050-1
• Accession: NZ_CP054576
• Organism: Staphylococcus saprophyticus strain UTI-050

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: -
• Locus tag: HSZ50_RS13115
• Protein ID: WP_011276848.1
• Coordinates: 35133..35228 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	35246..35281 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSZ50_RS13075	30514..31188	+	675	WP_001105987.1	IS6-like element IS257 family transposase	-
HSZ50_RS13080	31393..32244	+	852	WP_040030568.1	NmrA family NAD(P)-binding protein	-
HSZ50_RS13085	32507..32659	+	153	WP_158501055.1	hypothetical protein	-
HSZ50_RS13090	32733..32900	-	168	WP_162837505.1	hypothetical protein	-
HSZ50_RS13095	32931..33161	-	231	WP_031884148.1	SHOCT domain-containing protein	-
HSZ50_RS13100	33295..33495	-	201	WP_073346352.1	hypothetical protein	-
HSZ50_RS13105	33984..34601	+	618	WP_002467537.1	CadD family cadmium resistance transporter	-
HSZ50_RS13110	34620..34967	+	348	WP_002467551.1	metalloregulator ArsR/SmtB family transcription factor	-
HSZ50_RS13115	35133..35228	+	96	WP_011276848.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	35246..35281	+	36	NuclAT_0	-	Antitoxin
HSZ50_RS13120	35583..36056	+	474	WP_077460978.1	thymidylate synthase	-
HSZ50_RS13125	36170..36598	+	429	WP_031885498.1	Rrf2 family transcriptional regulator	-
HSZ50_RS13130	36719..37294	+	576	Protein_42	DsbA family protein	-
HSZ50_RS13135	37311..37961	+	651	WP_031885497.1	NAD(P)-dependent oxidoreductase	-
HSZ50_RS13140	38260..39015	-	756	WP_031863945.1	sulfite exporter TauE/SafE family protein	-
HSZ50_RS13145	39015..39275	-	261	WP_031863946.1	persulfide-sensing transcriptional repressor CstR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..41251	41251
	-	flank	IS/Tn	-	-	30514..31188	674

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3623.38 Da
• Isoelectric Point: 9.5124

>T159920 WP_011276848.1 NZ_CP054576:35133-35228 [Staphylococcus saprophyticus]
MLEILVHITTTVISGCIIALFTHWLRNRKDK

Nucleotide

• Length: 96 bp

>T159920 NZ_CP070170:c4335179-4335006 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Nucleotide

• Length: 36 bp

>AT159920 NZ_CP054576:35246-35281 [Staphylococcus saprophyticus]
TACAAAAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin