Detailed information of TA system TA159907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 219413..220008
• Replicon: chromosome
• Accession: NZ_CP054572
• Organism: Pseudomonas sp. FDAARGOS_761

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A6N0KDU0
• Locus tag: FOC67_RS01025
• Protein ID: WP_023436306.1
• Coordinates: 219413..219691 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FOC67_RS01030
• Protein ID: WP_003133769.1
• Coordinates: 219703..220008 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC67_RS01010	214838..216076	+	1239	WP_009316205.1	C69 family dipeptidase	-
FOC67_RS01015	216138..216785	+	648	WP_003095021.1	carbonate dehydratase	-
FOC67_RS01020	216856..219084	-	2229	WP_009316206.1	TonB-dependent receptor	-
FOC67_RS01025	219413..219691	+	279	WP_023436306.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOC67_RS01030	219703..220008	+	306	WP_003133769.1	HigA family addiction module antidote protein	Antitoxin
FOC67_RS01040	220305..221435	-	1131	WP_009316207.1	AraC family transcriptional regulator ligand-binding domain-containing protein	-
FOC67_RS01045	221730..222656	+	927	WP_009316208.1	triacylglycerol lipase	-
FOC67_RS01050	222736..223779	+	1044	WP_049321234.1	lipase secretion chaperone	-
FOC67_RS01055	223864..224964	-	1101	WP_003099270.1	redox-regulated ATPase YchF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-82)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10588.11 Da
• Isoelectric Point: 7.2451

>T159907 WP_023436306.1 NZ_CP054572:219413-219691 [Pseudomonas sp. FDAARGOS_761]
MILTFRCDEARQLFETGLSRQWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Nucleotide

• Length: 279 bp

>T159907 NZ_CP070170:1013974-1014309 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11214.73 Da
• Isoelectric Point: 4.6081

>AT159907 WP_003133769.1 NZ_CP054572:219703-220008 [Pseudomonas sp. FDAARGOS_761]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Nucleotide

• Length: 306 bp

>AT159907 NZ_CP070170:1013726-1013974 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGATCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: A0A6N0KDU0