Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1478437..1479042 Replicon chromosome
Accession NZ_CP054492
Organism Candidatus Sulfurimonas baltica strain GD2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HUE88_RS07445 Protein ID WP_194368099.1
Coordinates 1478749..1479042 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HUE88_RS07440 Protein ID WP_194368098.1
Coordinates 1478437..1478736 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE88_RS07430 1473749..1476361 - 2613 WP_194368096.1 PAS domain S-box protein -
HUE88_RS07435 1476709..1478376 + 1668 WP_194368097.1 diguanylate cyclase -
HUE88_RS07440 1478437..1478736 - 300 WP_194368098.1 HigA family addiction module antidote protein Antitoxin
HUE88_RS07445 1478749..1479042 - 294 WP_194368099.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUE88_RS07450 1479110..1479673 + 564 WP_194368100.1 recombinase family protein -
HUE88_RS07455 1479846..1481825 - 1980 WP_194368101.1 molybdopterin oxidoreductase family protein -
HUE88_RS07460 1482024..1483670 + 1647 WP_194368102.1 protein phosphatase 2C domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-70)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11157.00 Da        Isoelectric Point: 9.1445

>T159802 WP_194368099.1 NZ_CP054492:c1479042-1478749 [Candidatus Sulfurimonas baltica]
MIVSFKDVVTENIFNGVTSKQAMKRLPNKLWKIAARKLDQLDSVIILDELKVPPGNHLEKLSGDRNGQCSIRINQQYRIC
FMWTVSGPDKVEIIDYH

Download         Length: 294 bp

>T159802 NZ_CP070148:c1891347-1891240 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11707.58 Da        Isoelectric Point: 7.3184

>AT159802 WP_194368098.1 NZ_CP054492:c1478736-1478437 [Candidatus Sulfurimonas baltica]
MRIPTHREPTHPGEMLLEEFLEPMNLTQRMLADAIHVPYQRINEIVNMKRGVTPSTALRLAKYFGVSEDFWLNLQTRWDI
YRSKKIEAEELERIKPLAS

Download         Length: 300 bp

>AT159802 NZ_CP070148:1891400-1891461 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References