Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-Phd
Location 2292680..2293182 Replicon chromosome
Accession NZ_CP054477
Organism Treponema denticola strain OMZ 823

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E2EC53
Locus tag E4N80_RS10840 Protein ID WP_002672679.1
Coordinates 2292922..2293182 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E2ECR9
Locus tag E4N80_RS10835 Protein ID WP_002672677.1
Coordinates 2292680..2292922 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N80_RS10810 (E4N80_10785) 2288851..2290131 - 1281 WP_253699218.1 amino acid permease -
E4N80_RS10815 (E4N80_10790) 2290182..2290907 - 726 WP_253699219.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
E4N80_RS10820 (E4N80_10795) 2290961..2291938 - 978 WP_253699220.1 hypothetical protein -
E4N80_RS10825 (E4N80_10800) 2292120..2292353 + 234 WP_002692434.1 hypothetical protein -
E4N80_RS10830 (E4N80_10805) 2292346..2292618 + 273 WP_002692432.1 type II toxin-antitoxin system RelE/ParE family toxin -
E4N80_RS10835 (E4N80_10810) 2292680..2292922 + 243 WP_002672677.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E4N80_RS10840 (E4N80_10815) 2292922..2293182 + 261 WP_002672679.1 Txe/YoeB family addiction module toxin Toxin
E4N80_RS10845 (E4N80_10820) 2293231..2293641 + 411 WP_253699221.1 hypothetical protein -
E4N80_RS10850 (E4N80_10825) 2294049..2296745 - 2697 WP_253696361.1 protein kinase/lanthionine synthetase C family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(18-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10379.10 Da        Isoelectric Point: 10.1554

>T159794 WP_002672679.1 NZ_CP054477:2292922-2293182 [Treponema denticola]
MWNVVYSKQAAKDSKKIEQSNLKESVKRLIEVLKNDPFQNPPPYEKLIGDLTGKFSRRINLQHRLVYEVFEKEMIVRVLR
MWTHYE

Download         Length: 261 bp

>T159794 NZ_CP070144:4904972-4905075 [Klebsiella oxytoca]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTTTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9175.34 Da        Isoelectric Point: 4.1317

>AT159794 WP_002672677.1 NZ_CP054477:2292680-2292922 [Treponema denticola]
MTIMTATAARTNLYNLIDRTKEFHEPIIISGKRNNAVLISEDDWNSIQETLYLCSIPGMRESILEASEESLEESVKELDW

Download         Length: 243 bp

>AT159794 NZ_CP070144:c4905082-4904937 [Klebsiella oxytoca]
AAAAGATAAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2EC53

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2ECR9

References