Detailed information of TA system TA159791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1519629..1520255
• Replicon: chromosome
• Accession: NZ_CP054477
• Organism: Treponema denticola strain OMZ 823

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q73NN6
• Locus tag: E4N80_RS07080
• Protein ID: WP_002677634.1
• Coordinates: 1519629..1519937 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: E4N80_RS07085
• Protein ID: WP_253698449.1
• Coordinates: 1519947..1520255 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N80_RS07055 (E4N80_07030)	1515582..1515920	+	339	WP_010696721.1	anti-sigma factor antagonist	-
E4N80_RS07060 (E4N80_07035)	1515937..1516479	+	543	WP_253698445.1	ATP-binding protein	-
E4N80_RS07065 (E4N80_07040)	1516493..1517314	-	822	WP_253698446.1	hypothetical protein	-
E4N80_RS07070 (E4N80_07045)	1517295..1517915	-	621	WP_253698447.1	hypothetical protein	-
E4N80_RS07075 (E4N80_07050)	1518032..1519411	+	1380	WP_253698448.1	tyrosine phenol-lyase	-
E4N80_RS07080 (E4N80_07055)	1519629..1519937	+	309	WP_002677634.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E4N80_RS07085 (E4N80_07060)	1519947..1520255	+	309	WP_253698449.1	NadS family protein	Antitoxin
E4N80_RS07090 (E4N80_07065)	1520388..1521059	+	672	WP_253698450.1	TetR/AcrR family transcriptional regulator	-
E4N80_RS07095 (E4N80_07070)	1521148..1521564	+	417	WP_253698451.1	SRPBCC family protein	-
E4N80_RS07100 (E4N80_07075)	1521707..1522336	-	630	WP_253698452.1	adenylate kinase	-
E4N80_RS07105 (E4N80_07080)	1522395..1523624	-	1230	WP_253698453.1	cation:dicarboxylase symporter family transporter	-
E4N80_RS07110 (E4N80_07085)	1523663..1524982	-	1320	WP_253698454.1	leucine-rich repeat domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-86)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11736.96 Da
• Isoelectric Point: 10.6864

>T159791 WP_002677634.1 NZ_CP054477:1519629-1519937 [Treponema denticola]
MRIIETPVFTKQINRLLDEDTYKQFKEYLVCNPLKGKLIKGGGGIRKIRWSKKNTGKSGGIRIIYFIKTETKIYLLFAYS
KSDAESITKKQINMLASFIKGL

Nucleotide

• Length: 309 bp

>T159791 NZ_CP070144:c1966763-1966443 [Klebsiella oxytoca]
ATGAAAACTCTACCTGCAATAAATCCGCAGGCGGCGACGCTATGTCTGTCGCCCGTGGCAGTCTGGCAAAAGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGACTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCTGGAACATATCT
ATGCCGGTATATCTTTGGCCGATGCCGTGAATTTTCTGGTGGAAAAGTATGAGCTGGTTCGTATTGATCGCAGAGGGTTT
AACTGGCGGGAGCAATCACCTTATCTTCAAGTTGTAGATATCCTGCGGGTACGACAAGCTATTGGCAGCTCAAGCAAGTA
A

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11579.46 Da
• Isoelectric Point: 9.6884

>AT159791 WP_253698449.1 NZ_CP054477:1519947-1520255 [Treponema denticola]
MFKRKKMSDEMFTELLQSVKEAVLIEKGEIPPSRVFEIEPLDIAKIRSKTNKTQEEFASMLNISIGTLRNWEQGRRKPDG
AALSLLKIVSANPQYVESVLQG

Nucleotide

• Length: 309 bp

>AT159791 NZ_CP070144:c1967125-1966784 [Klebsiella oxytoca]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCCAGTGGGGACTGAATCGTAATGTGACGCCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGTTGACCGGGCCAGCATTACCGGTGAATTCAGTAACGCAGAATCTT
TGAAGTTGGATGAAGTATTCCCACATTTTATCAGCCAGATGGAGTCGATGTTGACTACTGGTGAATTGAATCCTCGGCAT
GCCCACTGTTTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CATTTACCCCACTCAGCGCTAA

Structures

Toxin

• AlphaFold DB: Q73NN6