Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 388896..389516 Replicon chromosome
Accession NZ_CP054469
Organism Burkholderia gladioli strain CGB10

Toxin (Protein)


Gene name higB Uniprot ID A0A838CB01
Locus tag HUB32_RS20910 Protein ID WP_046574672.1
Coordinates 389238..389516 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A560VTG3
Locus tag HUB32_RS20905 Protein ID WP_029951048.1
Coordinates 388896..389219 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUB32_RS20885 384612..385025 - 414 WP_013690200.1 MarR family transcriptional regulator -
HUB32_RS20890 385133..386250 - 1118 Protein_321 HPP family protein -
HUB32_RS20895 386704..387660 + 957 WP_013690202.1 LysR family transcriptional regulator -
HUB32_RS20900 387703..388788 - 1086 WP_036056417.1 ionic transporter y4hA -
HUB32_RS20905 388896..389219 - 324 WP_029951048.1 HigA family addiction module antidote protein Antitoxin
HUB32_RS20910 389238..389516 - 279 WP_046574672.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUB32_RS20915 389759..390427 + 669 WP_025100406.1 NAAT family transporter -
HUB32_RS20920 390540..391409 - 870 WP_013690207.1 CPBP family intramembrane metalloprotease -
HUB32_RS20925 391683..392405 - 723 WP_186289089.1 fumarylacetoacetate hydrolase family protein -
HUB32_RS20930 392554..393654 - 1101 WP_105848813.1 helix-turn-helix transcriptional regulator -
HUB32_RS20935 393847..394449 - 603 WP_013690210.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(13-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10401.00 Da        Isoelectric Point: 9.9309

>T159767 WP_046574672.1 NZ_CP054469:c389516-389238 [Burkholderia gladioli]
MIQSFRCKRTAALFAGESPPAWRAVAQVARRKLAMLDAAQALRDLAVPPGNQLEGLFGDRAGQYSIRINERWRLCFVWSS
RGPELVEIVDYH

Download         Length: 279 bp

>T159767 NZ_CP070134:c1671883-1671548 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11903.72 Da        Isoelectric Point: 7.2024

>AT159767 WP_029951048.1 NZ_CP054469:c389219-388896 [Burkholderia gladioli]
MNAKSVKPVNAMPAIHPGEILREEFLVPLALSVNALSLALMVPATRMHEIVNERRGITADTAYRLSRYFGTTPEFWLALQ
ADYDIKTLPNRDEIDRKVDARPNGAAA

Download         Length: 324 bp

>AT159767 NZ_CP070134:c1672131-1671883 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A838CB01

Antitoxin

Source ID Structure
AlphaFold DB A0A560VTG3

References