Detailed information of TA system TA159761

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 2246256..2246733
• Replicon: chromosome
• Accession: NZ_CP054444
• Organism: Staphylococcus saprophyticus strain UTI-056

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: HSZ51_RS11065
• Protein ID: WP_041080397.1
• Coordinates: 2246256..2246513 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2246565..2246733 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSZ51_RS11035	2241291..2241368	-	78	WP_115340783.1	hypothetical protein	-
HSZ51_RS11040	2242443..2242853	-	411	WP_011303346.1	YolD-like family protein	-
HSZ51_RS11045	2242863..2243054	-	192	WP_011303347.1	hypothetical protein	-
HSZ51_RS11050	2243150..2243398	-	249	WP_061050614.1	GlsB/YeaQ/YmgE family stress response membrane protein	-
HSZ51_RS11055	2243991..2244500	-	510	WP_061050616.1	DUF4065 domain-containing protein	-
HSZ51_RS11060	2244881..2245828	-	948	WP_061050681.1	peptidoglycan recognition protein family protein	-
HSZ51_RS11065	2246256..2246513	-	258	WP_041080397.1	phage holin	Toxin
-	2246565..2246733	+	169	-	-	Antitoxin
HSZ51_RS11075	2246914..2247201	-	288	WP_041080395.1	hypothetical protein	-
HSZ51_RS11080	2247236..2249119	-	1884	WP_061050617.1	glucosaminidase domain-containing protein	-
HSZ51_RS11085	2249173..2249505	-	333	WP_061050618.1	DUF2977 domain-containing protein	-
HSZ51_RS11090	2249505..2251370	-	1866	WP_061050619.1	phage baseplate upper protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2232424..2283499	51075

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (6-68)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9352.18 Da
• Isoelectric Point: 10.2507

>T159761 WP_041080397.1 NZ_CP054444:c2246513-2246256 [Staphylococcus saprophyticus]
MDVKVTVIVRVLGLVLVLVNQCLANKGVSPIPVDESTLMTIAVALITAWKDNPLTNAAKESNKVMKELKTQNKYEKVVMR
SGKEK

Nucleotide

• Length: 258 bp

>T159761 NZ_CP070134:c231729-231553 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCGTGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Nucleotide

• Length: 169 bp

>AT159761 NZ_CP054444:2246565-2246733 [Staphylococcus saprophyticus]
ATTTGATAATATTTTTATGTTGTGTTAATTTATATATAGAAAAAGGGCAACACACATATGTGTATCGCCCAAATGAGCCC
GTTAAAAAGACGGTGGCATAGAGATAATTAAATATTAATAAAACCTTTTAACCATCTGCTCGCCAAAGCTATAGATGGTT
ATTTTTTAT

Structures

Antitoxin