Detailed information of TA system TA159749

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 1702635..1703112
• Replicon: chromosome
• Accession: NZ_CP054440
• Organism: Staphylococcus saprophyticus strain UTI-058y

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: HSZ52_RS08345
• Protein ID: WP_041080397.1
• Coordinates: 1702635..1702892 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1702944..1703112 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSZ52_RS08315	1697670..1697747	-	78	WP_115340783.1	hypothetical protein	-
HSZ52_RS08320	1698822..1699232	-	411	WP_011303346.1	YolD-like family protein	-
HSZ52_RS08325	1699242..1699433	-	192	WP_011303347.1	hypothetical protein	-
HSZ52_RS08330	1699529..1699777	-	249	WP_061050614.1	GlsB/YeaQ/YmgE family stress response membrane protein	-
HSZ52_RS08335	1700370..1700879	-	510	WP_061050616.1	DUF4065 domain-containing protein	-
HSZ52_RS08340	1701260..1702207	-	948	WP_061050681.1	peptidoglycan recognition protein family protein	-
HSZ52_RS08345	1702635..1702892	-	258	WP_041080397.1	phage holin	Toxin
-	1702944..1703112	+	169	-	-	Antitoxin
HSZ52_RS08355	1703293..1703580	-	288	WP_041080395.1	hypothetical protein	-
HSZ52_RS08360	1703615..1705498	-	1884	WP_061050617.1	glucosaminidase domain-containing protein	-
HSZ52_RS08365	1705552..1705884	-	333	WP_061050618.1	DUF2977 domain-containing protein	-
HSZ52_RS08370	1705884..1707749	-	1866	WP_061050619.1	phage baseplate upper protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1695579..1739877	44298

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (6-68)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9352.18 Da
• Isoelectric Point: 10.2507

>T159749 WP_041080397.1 NZ_CP054440:c1702892-1702635 [Staphylococcus saprophyticus]
MDVKVTVIVRVLGLVLVLVNQCLANKGVSPIPVDESTLMTIAVALITAWKDNPLTNAAKESNKVMKELKTQNKYEKVVMR
SGKEK

Nucleotide

• Length: 258 bp

>T159749 NZ_CP070124:3394204-3395526 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGAGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAATGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCAAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACAGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTATGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin

Nucleotide

• Length: 169 bp

>AT159749 NZ_CP054440:1702944-1703112 [Staphylococcus saprophyticus]
ATTTGATAATATTTTTATGTTGTGTTAATTTATATATAGAAAAAGGGCAACACACATATGTGTATCGCCCAAATGAGCCC
GTTAAAAAGACGGTGGCATAGAGATAATTAAATATTAATAAAACCTTTTAACCATCTGCTCGCCAAAGCTATAGATGGTT
ATTTTTTAT

Structures

Antitoxin