Detailed information of TA system TA159737

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 1716407..1716884
• Replicon: chromosome
• Accession: NZ_CP054434
• Organism: Staphylococcus saprophyticus strain UTI-035

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: HSZ47_RS08340
• Protein ID: WP_041080397.1
• Coordinates: 1716407..1716664 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1716716..1716884 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSZ47_RS08305	1711430..1711507	-	78	WP_115340783.1	hypothetical protein	-
HSZ47_RS08310	1712583..1712993	-	411	WP_047503486.1	YolD-like family protein	-
HSZ47_RS08315	1713003..1713194	-	192	WP_011303347.1	hypothetical protein	-
HSZ47_RS08320	1713290..1713538	-	249	WP_047503483.1	GlsB/YeaQ/YmgE family stress response membrane protein	-
HSZ47_RS08325	1713727..1714140	-	414	WP_107523634.1	type II toxin-antitoxin system PemK/MazF family toxin	-
HSZ47_RS08330	1714130..1714639	-	510	WP_061050616.1	DUF4065 domain-containing protein	-
HSZ47_RS08335	1715032..1715979	-	948	WP_174538821.1	peptidoglycan recognition protein family protein	-
HSZ47_RS08340	1716407..1716664	-	258	WP_041080397.1	phage holin	Toxin
-	1716716..1716884	+	169	-	-	Antitoxin
HSZ47_RS08350	1717065..1717352	-	288	WP_041080395.1	hypothetical protein	-
HSZ47_RS08355	1717387..1719273	-	1887	WP_174538747.1	glucosaminidase domain-containing protein	-
HSZ47_RS08360	1719329..1719661	-	333	WP_174538748.1	DUF2977 domain-containing protein	-
HSZ47_RS08365	1719661..1721526	-	1866	WP_174538749.1	BppU family phage baseplate upper protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1709339..1754962	45623

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (6-68)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9352.18 Da
• Isoelectric Point: 10.2507

>T159737 WP_041080397.1 NZ_CP054434:c1716664-1716407 [Staphylococcus saprophyticus]
MDVKVTVIVRVLGLVLVLVNQCLANKGVSPIPVDESTLMTIAVALITAWKDNPLTNAAKESNKVMKELKTQNKYEKVVMR
SGKEK

Nucleotide

• Length: 258 bp

>T159737 NZ_CP070124:c349926-349753 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Nucleotide

• Length: 169 bp

>AT159737 NZ_CP054434:1716716-1716884 [Staphylococcus saprophyticus]
ATTTGATAATATTTTTATGTTGTGTTAATTTATATATAGAAAAAGGGCAACACACATATGTGTATCGCCCAAATGAGCCC
GTTAAAAAGACGGTGGCATAGAGATAATTAAATATTAATAAAACCTTTTAACCATCTGCTCGCCAAAGCTATAGATGGTT
ATTTTTTAT

Structures

Antitoxin