Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3742108..3742765 Replicon chromosome
Accession NZ_CP054410
Organism Enterobacter hormaechei strain KCJ3K13

Toxin (Protein)


Gene name higB Uniprot ID A0A837FDC1
Locus tag FCG85_RS18410 Protein ID WP_015571638.1
Coordinates 3742108..3742407 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0F0ZCT3
Locus tag FCG85_RS18415 Protein ID WP_022651701.1
Coordinates 3742418..3742765 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCG85_RS18400 (FCG85_018395) 3738485..3740677 + 2193 WP_137041666.1 type I secretion system permease/ATPase -
FCG85_RS18405 (FCG85_018400) 3740658..3741857 + 1200 WP_232970423.1 HlyD family efflux transporter periplasmic adaptor subunit -
FCG85_RS18410 (FCG85_018405) 3742108..3742407 + 300 WP_015571638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FCG85_RS18415 (FCG85_018410) 3742418..3742765 + 348 WP_022651701.1 HigA family addiction module antitoxin Antitoxin
FCG85_RS18420 (FCG85_018415) 3742841..3744022 - 1182 WP_023314694.1 PLP-dependent aminotransferase family protein -
FCG85_RS18425 (FCG85_018420) 3744043..3744930 - 888 WP_045343785.1 LysR substrate-binding domain-containing protein -
FCG85_RS18430 (FCG85_018425) 3745028..3745630 + 603 WP_137041667.1 short chain dehydrogenase -
FCG85_RS18435 (FCG85_018430) 3745627..3745791 - 165 WP_232970422.1 hypothetical protein -
FCG85_RS18440 (FCG85_018435) 3745788..3746786 - 999 WP_022651706.1 transketolase family protein -
FCG85_RS18445 (FCG85_018440) 3746786..3747631 - 846 WP_022651707.1 transketolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11624.29 Da        Isoelectric Point: 9.6776

>T159704 WP_015571638.1 NZ_CP054410:3742108-3742407 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T159704 NZ_CP070111:3658658-3658765 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13096.09 Da        Isoelectric Point: 9.5932

>AT159704 WP_022651701.1 NZ_CP054410:3742418-3742765 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVA

Download         Length: 348 bp

>AT159704 NZ_CP070111:c3658601-3658543 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FDC1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F0ZCT3

References