Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 338398..339044 Replicon chromosome
Accession NZ_CP054406
Organism Klebsiella pneumoniae strain KCJ3K293

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FOH49_RS03200 Protein ID WP_023317328.1
Coordinates 338398..338745 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FOH49_RS03205 Protein ID WP_032412314.1
Coordinates 338745..339044 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOH49_RS03190 (FOH49_003200) 334324..335757 + 1434 WP_002920564.1 glycogen synthase GlgA -
FOH49_RS03195 (FOH49_003205) 335775..338222 + 2448 WP_002920561.1 glycogen phosphorylase -
FOH49_RS03200 (FOH49_003210) 338398..338745 + 348 WP_023317328.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOH49_RS03205 (FOH49_003215) 338745..339044 + 300 WP_032412314.1 XRE family transcriptional regulator Antitoxin
FOH49_RS03210 (FOH49_003220) 339107..340615 - 1509 WP_032412313.1 glycerol-3-phosphate dehydrogenase -
FOH49_RS03215 (FOH49_003225) 340820..341149 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
FOH49_RS03220 (FOH49_003230) 341200..342030 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
FOH49_RS03225 (FOH49_003235) 342080..342838 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13562.60 Da        Isoelectric Point: 6.2327

>T159644 WP_023317328.1 NZ_CP054406:338398-338745 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
ILCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T159644 NZ_CP070101:1952012-1952263 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10828.64 Da        Isoelectric Point: 10.1464

>AT159644 WP_032412314.1 NZ_CP054406:338745-339044 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGIKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT159644 NZ_CP070101:1952266-1952667 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References