Detailed information of TA system TA159568

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 1380035..1380255
• Replicon: chromosome
• Accession: NZ_CP054388
• Organism: Escherichia coli strain 1517k

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1PGT3
• Locus tag: E2126_RS06470
• Protein ID: WP_000170954.1
• Coordinates: 1380035..1380142 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	1380192..1380255 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E2126_RS06445	1375879..1376961	+	1083	WP_000804726.1	peptide chain release factor 1	-
E2126_RS06450	1376961..1377794	+	834	WP_000456458.1	peptide chain release factor N(5)-glutamine methyltransferase	-
E2126_RS06455	1377791..1378183	+	393	WP_000200374.1	invasion regulator SirB2	-
E2126_RS06460	1378187..1378996	+	810	WP_001257044.1	invasion regulator SirB1	-
E2126_RS06465	1379032..1379886	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
E2126_RS06470	1380035..1380142	-	108	WP_000170954.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	1380192..1380255	+	64	NuclAT_51	-	Antitoxin
-	1380192..1380255	+	64	NuclAT_51	-	Antitoxin
-	1380192..1380255	+	64	NuclAT_51	-	Antitoxin
-	1380192..1380255	+	64	NuclAT_51	-	Antitoxin
-	1380192..1380255	+	64	NuclAT_54	-	Antitoxin
-	1380192..1380255	+	64	NuclAT_54	-	Antitoxin
-	1380192..1380255	+	64	NuclAT_54	-	Antitoxin
-	1380192..1380255	+	64	NuclAT_54	-	Antitoxin
-	1380192..1380255	+	64	NuclAT_57	-	Antitoxin
-	1380192..1380255	+	64	NuclAT_57	-	Antitoxin
-	1380192..1380255	+	64	NuclAT_57	-	Antitoxin
-	1380192..1380255	+	64	NuclAT_57	-	Antitoxin
-	1380192..1380255	+	64	NuclAT_60	-	Antitoxin
-	1380192..1380255	+	64	NuclAT_60	-	Antitoxin
-	1380192..1380255	+	64	NuclAT_60	-	Antitoxin
-	1380192..1380255	+	64	NuclAT_60	-	Antitoxin
E2126_RS06475	1380570..1380677	-	108	WP_000170926.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	1380730..1380791	+	62	NuclAT_50	-	-
-	1380730..1380791	+	62	NuclAT_50	-	-
-	1380730..1380791	+	62	NuclAT_50	-	-
-	1380730..1380791	+	62	NuclAT_50	-	-
-	1380730..1380791	+	62	NuclAT_53	-	-
-	1380730..1380791	+	62	NuclAT_53	-	-
-	1380730..1380791	+	62	NuclAT_53	-	-
-	1380730..1380791	+	62	NuclAT_53	-	-
-	1380730..1380791	+	62	NuclAT_56	-	-
-	1380730..1380791	+	62	NuclAT_56	-	-
-	1380730..1380791	+	62	NuclAT_56	-	-
-	1380730..1380791	+	62	NuclAT_56	-	-
-	1380730..1380791	+	62	NuclAT_59	-	-
-	1380730..1380791	+	62	NuclAT_59	-	-
-	1380730..1380791	+	62	NuclAT_59	-	-
-	1380730..1380791	+	62	NuclAT_59	-	-
-	1380730..1380793	+	64	NuclAT_13	-	-
-	1380730..1380793	+	64	NuclAT_13	-	-
-	1380730..1380793	+	64	NuclAT_13	-	-
-	1380730..1380793	+	64	NuclAT_13	-	-
-	1380730..1380793	+	64	NuclAT_15	-	-
-	1380730..1380793	+	64	NuclAT_15	-	-
-	1380730..1380793	+	64	NuclAT_15	-	-
-	1380730..1380793	+	64	NuclAT_15	-	-
-	1380730..1380793	+	64	NuclAT_17	-	-
-	1380730..1380793	+	64	NuclAT_17	-	-
-	1380730..1380793	+	64	NuclAT_17	-	-
-	1380730..1380793	+	64	NuclAT_17	-	-
-	1380730..1380793	+	64	NuclAT_19	-	-
-	1380730..1380793	+	64	NuclAT_19	-	-
-	1380730..1380793	+	64	NuclAT_19	-	-
-	1380730..1380793	+	64	NuclAT_19	-	-
-	1380730..1380793	+	64	NuclAT_21	-	-
-	1380730..1380793	+	64	NuclAT_21	-	-
-	1380730..1380793	+	64	NuclAT_21	-	-
-	1380730..1380793	+	64	NuclAT_21	-	-
-	1380730..1380793	+	64	NuclAT_23	-	-
-	1380730..1380793	+	64	NuclAT_23	-	-
-	1380730..1380793	+	64	NuclAT_23	-	-
-	1380730..1380793	+	64	NuclAT_23	-	-
E2126_RS06480	1381106..1381213	-	108	WP_000170965.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	1381261..1381326	+	66	NuclAT_49	-	-
-	1381261..1381326	+	66	NuclAT_49	-	-
-	1381261..1381326	+	66	NuclAT_49	-	-
-	1381261..1381326	+	66	NuclAT_49	-	-
-	1381261..1381326	+	66	NuclAT_52	-	-
-	1381261..1381326	+	66	NuclAT_52	-	-
-	1381261..1381326	+	66	NuclAT_52	-	-
-	1381261..1381326	+	66	NuclAT_52	-	-
-	1381261..1381326	+	66	NuclAT_55	-	-
-	1381261..1381326	+	66	NuclAT_55	-	-
-	1381261..1381326	+	66	NuclAT_55	-	-
-	1381261..1381326	+	66	NuclAT_55	-	-
-	1381261..1381326	+	66	NuclAT_58	-	-
-	1381261..1381326	+	66	NuclAT_58	-	-
-	1381261..1381326	+	66	NuclAT_58	-	-
-	1381261..1381326	+	66	NuclAT_58	-	-
-	1381261..1381328	+	68	NuclAT_12	-	-
-	1381261..1381328	+	68	NuclAT_12	-	-
-	1381261..1381328	+	68	NuclAT_12	-	-
-	1381261..1381328	+	68	NuclAT_12	-	-
-	1381261..1381328	+	68	NuclAT_14	-	-
-	1381261..1381328	+	68	NuclAT_14	-	-
-	1381261..1381328	+	68	NuclAT_14	-	-
-	1381261..1381328	+	68	NuclAT_14	-	-
-	1381261..1381328	+	68	NuclAT_16	-	-
-	1381261..1381328	+	68	NuclAT_16	-	-
-	1381261..1381328	+	68	NuclAT_16	-	-
-	1381261..1381328	+	68	NuclAT_16	-	-
-	1381261..1381328	+	68	NuclAT_18	-	-
-	1381261..1381328	+	68	NuclAT_18	-	-
-	1381261..1381328	+	68	NuclAT_18	-	-
-	1381261..1381328	+	68	NuclAT_18	-	-
-	1381261..1381328	+	68	NuclAT_20	-	-
-	1381261..1381328	+	68	NuclAT_20	-	-
-	1381261..1381328	+	68	NuclAT_20	-	-
-	1381261..1381328	+	68	NuclAT_20	-	-
-	1381261..1381328	+	68	NuclAT_22	-	-
-	1381261..1381328	+	68	NuclAT_22	-	-
-	1381261..1381328	+	68	NuclAT_22	-	-
-	1381261..1381328	+	68	NuclAT_22	-	-
E2126_RS06485	1381618..1382718	-	1101	WP_001295620.1	sodium-potassium/proton antiporter ChaA	-
E2126_RS06490	1382988..1383218	+	231	WP_001146442.1	putative cation transport regulator ChaB	-
E2126_RS06495	1383376..1384071	+	696	WP_012311798.1	glutathione-specific gamma-glutamylcyclotransferase	-
E2126_RS06500	1384115..1384468	-	354	WP_001169669.1	DsrE/F sulfur relay family protein YchN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3983.80 Da
• Isoelectric Point: 11.4779

>T159568 WP_000170954.1 NZ_CP054388:c1380142-1380035 [Escherichia coli]
MTLAQFAMIFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T159568 NZ_CP070077:3233704-3234039 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGAGCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 64 bp

>AT159568 NZ_CP054388:1380192-1380255 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A7U9LPE9

Antitoxin