Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4923816..4924418 Replicon chromosome
Accession NZ_CP054371
Organism Escherichia coli strain SCU-316

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag HPE41_RS23245 Protein ID WP_000897305.1
Coordinates 4923816..4924127 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HPE41_RS23250 Protein ID WP_000356397.1
Coordinates 4924128..4924418 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE41_RS23225 4918863..4919300 + 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
HPE41_RS23230 4919345..4920286 + 942 WP_001343389.1 fatty acid biosynthesis protein FabY -
HPE41_RS23235 4920697..4922511 + 1815 WP_000226343.1 hypothetical protein -
HPE41_RS23240 4922679..4923587 - 909 WP_023155176.1 alpha/beta hydrolase -
HPE41_RS23245 4923816..4924127 + 312 WP_000897305.1 hypothetical protein Toxin
HPE41_RS23250 4924128..4924418 + 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
HPE41_RS23255 4925002..4925220 + 219 WP_001313440.1 ribbon-helix-helix domain-containing protein -
HPE41_RS23260 4925439..4925681 + 243 WP_001086385.1 hypothetical protein -
HPE41_RS23265 4926011..4926940 - 930 WP_000027691.1 formate dehydrogenase accessory protein FdhE -
HPE41_RS23270 4926937..4927572 - 636 WP_000829031.1 formate dehydrogenase cytochrome b556 subunit -
HPE41_RS23275 4927569..4928471 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12172.16 Da        Isoelectric Point: 9.7791

>T159564 WP_000897305.1 NZ_CP054371:4923816-4924127 [Escherichia coli]
ILFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T159564 NZ_CP070077:2362678-2362785 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT159564 WP_000356397.1 NZ_CP054371:4924128-4924418 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT159564 NZ_CP070077:c2362629-2362566 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References