Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3310995..3312313 Replicon chromosome
Accession NZ_CP054368
Organism Escherichia coli strain SCU-115

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag HPE48_RS16065 Protein ID WP_021560080.1
Coordinates 3311306..3312313 (+) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag HPE48_RS16060 Protein ID WP_105453656.1
Coordinates 3310995..3311306 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE48_RS16030 3306282..3306509 - 228 WP_000198576.1 hypothetical protein -
HPE48_RS16035 3306527..3307546 + 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -
HPE48_RS16040 3307556..3308458 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
HPE48_RS16045 3308469..3309452 + 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
HPE48_RS16050 3309449..3310462 + 1014 WP_157702495.1 dipeptide ABC transporter ATP-binding subunit DppF -
HPE48_RS16055 3310687..3311010 + 324 WP_021560081.1 helix-turn-helix transcriptional regulator -
HPE48_RS16060 3310995..3311306 + 312 WP_105453656.1 HipA N-terminal domain-containing protein Antitoxin
HPE48_RS16065 3311306..3312313 + 1008 WP_021560080.1 HipA domain-containing protein Toxin
HPE48_RS16070 3312330..3313601 - 1272 WP_105454295.1 amino acid permease -
- 3313963..3314028 - 66 NuclAT_24 - -
- 3313963..3314028 - 66 NuclAT_24 - -
- 3313963..3314028 - 66 NuclAT_24 - -
- 3313963..3314028 - 66 NuclAT_24 - -
- 3313963..3314028 - 66 NuclAT_25 - -
- 3313963..3314028 - 66 NuclAT_25 - -
- 3313963..3314028 - 66 NuclAT_25 - -
- 3313963..3314028 - 66 NuclAT_25 - -
HPE48_RS16075 3314077..3314184 + 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
HPE48_RS16080 3314560..3314667 + 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
HPE48_RS16085 3314753..3316432 - 1680 WP_001527888.1 cellulose biosynthesis protein BcsG -
HPE48_RS16090 3316429..3316620 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-99)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38395.65 Da        Isoelectric Point: 5.4135

>T159522 WP_021560080.1 NZ_CP054368:3311306-3312313 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDYKGLPVHQEQLDGAMQITD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPTLAPVYDFVSVAPY
PEYFYSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

>T159522 NZ_CP070071:293012-293410 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAACATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11804.37 Da        Isoelectric Point: 6.0609

>AT159522 WP_105453656.1 NZ_CP054368:3310995-3311306 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAQDYHGPAISISLPVAQRQFPSETLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGILIDNGKNLLGAIQILPWEE

Download         Length: 312 bp

>AT159522 NZ_CP070071:292785-293012 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References