Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
| Location | 3310995..3312313 | Replicon | chromosome |
| Accession | NZ_CP054368 | ||
| Organism | Escherichia coli strain SCU-115 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | - |
| Locus tag | HPE48_RS16065 | Protein ID | WP_021560080.1 |
| Coordinates | 3311306..3312313 (+) | Length | 336 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | - |
| Locus tag | HPE48_RS16060 | Protein ID | WP_105453656.1 |
| Coordinates | 3310995..3311306 (+) | Length | 104 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPE48_RS16030 | 3306282..3306509 | - | 228 | WP_000198576.1 | hypothetical protein | - |
| HPE48_RS16035 | 3306527..3307546 | + | 1020 | WP_000938855.1 | dipeptide ABC transporter permease DppB | - |
| HPE48_RS16040 | 3307556..3308458 | + | 903 | WP_000084677.1 | dipeptide ABC transporter permease DppC | - |
| HPE48_RS16045 | 3308469..3309452 | + | 984 | WP_001196477.1 | dipeptide ABC transporter ATP-binding protein | - |
| HPE48_RS16050 | 3309449..3310462 | + | 1014 | WP_157702495.1 | dipeptide ABC transporter ATP-binding subunit DppF | - |
| HPE48_RS16055 | 3310687..3311010 | + | 324 | WP_021560081.1 | helix-turn-helix transcriptional regulator | - |
| HPE48_RS16060 | 3310995..3311306 | + | 312 | WP_105453656.1 | HipA N-terminal domain-containing protein | Antitoxin |
| HPE48_RS16065 | 3311306..3312313 | + | 1008 | WP_021560080.1 | HipA domain-containing protein | Toxin |
| HPE48_RS16070 | 3312330..3313601 | - | 1272 | WP_105454295.1 | amino acid permease | - |
| - | 3313963..3314028 | - | 66 | NuclAT_24 | - | - |
| - | 3313963..3314028 | - | 66 | NuclAT_24 | - | - |
| - | 3313963..3314028 | - | 66 | NuclAT_24 | - | - |
| - | 3313963..3314028 | - | 66 | NuclAT_24 | - | - |
| - | 3313963..3314028 | - | 66 | NuclAT_25 | - | - |
| - | 3313963..3314028 | - | 66 | NuclAT_25 | - | - |
| - | 3313963..3314028 | - | 66 | NuclAT_25 | - | - |
| - | 3313963..3314028 | - | 66 | NuclAT_25 | - | - |
| HPE48_RS16075 | 3314077..3314184 | + | 108 | WP_000170748.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| HPE48_RS16080 | 3314560..3314667 | + | 108 | WP_000170748.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| HPE48_RS16085 | 3314753..3316432 | - | 1680 | WP_001527888.1 | cellulose biosynthesis protein BcsG | - |
| HPE48_RS16090 | 3316429..3316620 | - | 192 | WP_000988308.1 | cellulose biosynthesis protein BcsF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 336 a.a. Molecular weight: 38395.65 Da Isoelectric Point: 5.4135
>T159522 WP_021560080.1 NZ_CP054368:3311306-3312313 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDYKGLPVHQEQLDGAMQITD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPTLAPVYDFVSVAPY
PEYFYSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDYKGLPVHQEQLDGAMQITD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPTLAPVYDFVSVAPY
PEYFYSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL
Download Length: 1008 bp
>T159522 NZ_CP070071:293012-293410 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAACATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA
ATGCTGAAATTCATGCTGGATACCAACATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA
Antitoxin
Download Length: 104 a.a. Molecular weight: 11804.37 Da Isoelectric Point: 6.0609
>AT159522 WP_105453656.1 NZ_CP054368:3310995-3311306 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAQDYHGPAISISLPVAQRQFPSETLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGILIDNGKNLLGAIQILPWEE
MHRRVKVLLYGQVVGELSQNDSGFLFQYAQDYHGPAISISLPVAQRQFPSETLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGILIDNGKNLLGAIQILPWEE
Download Length: 312 bp
>AT159522 NZ_CP070071:292785-293012 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|