Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3290221..3290477 Replicon chromosome
Accession NZ_CP054368
Organism Escherichia coli strain SCU-115

Toxin (Protein)


Gene name hokA Uniprot ID F4T5C6
Locus tag HPE48_RS15955 Protein ID WP_001135731.1
Coordinates 3290325..3290477 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 3290221..3290275 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE48_RS15935 3285449..3286444 - 996 WP_001182627.1 O-acetyltransferase WecH -
HPE48_RS15940 3286619..3286918 + 300 WP_000980102.1 YsaB family lipoprotein -
HPE48_RS15945 3287013..3287924 + 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
HPE48_RS15950 3287934..3290003 + 2070 WP_001291788.1 glycine--tRNA ligase subunit beta -
- 3290221..3290275 - 55 - - Antitoxin
HPE48_RS15955 3290325..3290477 + 153 WP_001135731.1 type I toxin-antitoxin system toxin HokA Toxin
HPE48_RS15960 3290665..3290877 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
HPE48_RS15965 3291158..3291448 - 291 WP_000455798.1 HTH-type transcriptional regulator -
HPE48_RS15970 3291882..3292592 + 711 WP_000190516.1 DUF3053 domain-containing protein -
HPE48_RS15975 3292642..3293616 - 975 WP_174144025.1 glyoxylate/hydroxypyruvate reductase GhrB -
HPE48_RS15980 3293720..3294379 - 660 WP_000747625.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 6025.30 Da        Isoelectric Point: 7.7169

>T159520 WP_001135731.1 NZ_CP054368:3290325-3290477 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Download         Length: 153 bp

>T159520 NZ_CP070070:c31769-31617 [Escherichia coli]
ATGCCACAGCGAACATTTTTAATGATGTTGATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGGCTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 55 bp

>AT159520 NZ_CP054368:c3290275-3290221 [Escherichia coli]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061YDD9

Antitoxin

Download structure file

References