Detailed information of TA system TA159487

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2651912..2652134
• Replicon: chromosome
• Accession: NZ_CP054363
• Organism: Escherichia coli strain SCU-171

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: HPE49_RS12780
• Protein ID: WP_001295224.1
• Coordinates: 2651912..2652019 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2652068..2652134 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPE49_RS12755	2647165..2647917	-	753	WP_000279544.1	cellulose biosynthesis protein BcsQ	-
HPE49_RS12760	2647929..2648117	-	189	WP_001063315.1	YhjR family protein	-
HPE49_RS12765	2648390..2649961	+	1572	WP_001204944.1	cellulose biosynthesis protein BcsE	-
HPE49_RS12770	2649958..2650149	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
HPE49_RS12775	2650146..2651825	+	1680	WP_001562264.1	cellulose biosynthesis protein BcsG	-
HPE49_RS12780	2651912..2652019	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2652068..2652134	+	67	-	-	Antitoxin
HPE49_RS12785	2652495..2653766	+	1272	WP_001318103.1	amino acid permease	-
HPE49_RS12790	2653796..2654800	-	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-
HPE49_RS12795	2654797..2655780	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
HPE49_RS12800	2655791..2656693	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T159487 WP_001295224.1 NZ_CP054363:c2652019-2651912 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T159487 NZ_CP070063:c2740348-2740070 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT159487 NZ_CP054363:2652068-2652134 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin