Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1932339..1933107 Replicon chromosome
Accession NZ_CP054353
Organism Escherichia coli strain SCU-172

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag HPE50_RS09350 Protein ID WP_000854814.1
Coordinates 1932339..1932713 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HPE50_RS09355 Protein ID WP_128857213.1
Coordinates 1932802..1933107 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE50_RS09310 1927743..1928963 + 1221 WP_000343765.1 ISL3-like element ISEc53 family transposase -
HPE50_RS09315 1929020..1929493 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
HPE50_RS09320 1929691..1930749 + 1059 WP_001200894.1 FUSC family protein -
HPE50_RS09325 1930921..1931250 + 330 WP_000450409.1 DUF496 family protein -
HPE50_RS09330 1931351..1931533 - 183 WP_001016348.1 hypothetical protein -
HPE50_RS09335 1931587..1931733 + 147 Protein_1802 transposase domain-containing protein -
HPE50_RS09340 1932022..1932135 - 114 WP_001161660.1 DUF957 domain-containing protein -
HPE50_RS09345 1932148..1932342 - 195 WP_000988601.1 hypothetical protein -
HPE50_RS09350 1932339..1932713 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
HPE50_RS09355 1932802..1933107 - 306 WP_128857213.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HPE50_RS09360 1933244..1933465 - 222 WP_000692323.1 DUF987 domain-containing protein -
HPE50_RS09365 1933528..1934004 - 477 WP_001186774.1 RadC family protein -
HPE50_RS09370 1934020..1934484 - 465 WP_001571600.1 antirestriction protein -
HPE50_RS09380 1937251..1937796 + 546 WP_000973199.1 bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1927743..1928963 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(2-96)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T159443 WP_000854814.1 NZ_CP054353:c1932713-1932339 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T159443 NZ_CP070046:2914305-2914625 [Klebsiella pneumoniae]
ATGTACATTTCAGCTGTACCGGCCACGGTGCCGGTTTCGTCACGTCTGTCGCCCGTGCAGGTCTGGCAGCAACTTTTAAC
GTATCTGCTGGATCACCATTACGGCCTGACGCTTAACGACACACCATTCCATGACGACGCGGCCATCAAGGAGCATATCG
ATGCAGGAATCACGCTCGCCGATGCTGTTAATTTTCTTGTGGAACGTTATGAACTGGTACGCATCGACCGCAAAGGGTTT
AGCTGGCAGGAACAGACTCCGTTCCTGACCGCGACTGATATTCTCCGAGCCAGGCGAGCTACCGGATTAATAAATACATA
A

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11084.76 Da        Isoelectric Point: 5.6182

>AT159443 WP_128857213.1 NZ_CP054353:c1933107-1932802 [Escherichia coli]
MPCTVTPCFGARLVQEGNRLHYLADRAGIRGLSSDADAYPLDQAFPLLMKQLELMLTSGELNPRTQHTVTLYAKGLACEA
DTLSSCGYVYLAVYPTPEMKN

Download         Length: 306 bp

>AT159443 NZ_CP070046:2913946-2914269 [Klebsiella pneumoniae]
ATGTCAATCACACCACCTCATGAATGGGGTCTACAAAGCGATATCACCCCACGATTTGGCGCGAGATTAGTTCAGGAAGG
CAATCGACTGCATTACCTGGCTGACAGGGCTGGATTGACGGGGAGTTTTAGCCCGATACACCTGCAGAAACTGGATCAGG
CTTTCCCGCTGTTTATAGAACAACTGGAAAATATGTTGCGCGTTGGCGAACTAAATCCACATCAGCAATATCATGTGACC
ATTCAACTTGCGAGTTTAACCTGTATAGCTGATACCCGTGGTAGCTGTGGCTACGTTTACATTTCTATCTATCCAACCCA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure

References