Detailed information of TA system TA159424

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3677965..3678223
• Replicon: chromosome
• Accession: NZ_CP054345
• Organism: Escherichia coli strain SCU-176

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HPE52_RS17690
• Protein ID: WP_001181672.1
• Coordinates: 3678014..3678223 (+)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3677965..3678022 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPE52_RS17675	3673794..3675053	-	1260	WP_000494929.1	hypothetical protein	-
HPE52_RS17680	3675182..3676675	-	1494	WP_001443162.1	sulfatase-like hydrolase/transferase	-
HPE52_RS17685	3676695..3677456	-	762	WP_001274832.1	hypothetical protein	-
-	3677965..3678022	-	58	-	-	Antitoxin
HPE52_RS17690	3678014..3678223	+	210	WP_001181672.1	type I toxin-antitoxin system Hok family toxin	Toxin
HPE52_RS17695	3678328..3679458	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
HPE52_RS17700	3679547..3681463	-	1917	WP_000516135.1	molecular chaperone DnaK	-
HPE52_RS17705	3681835..3682239	+	405	WP_000843687.1	DUF2541 family protein	-
HPE52_RS17710	3682265..3682978	+	714	WP_001102391.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7757.25 Da
• Isoelectric Point: 9.3680

>T159424 WP_001181672.1 NZ_CP054345:3678014-3678223 [Escherichia coli]
MQNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T159424 NZ_CP070045:c2250994-2250740 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT159424 NZ_CP054345:c3678022-3677965 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin