159419

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2111778..2112340 Replicon chromosome
Accession NZ_CP054345
Organism Escherichia coli strain SCU-176

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag HPE52_RS10110 Protein ID WP_000605675.1
Coordinates 2111778..2112056 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HPE52_RS10115 Protein ID WP_000781370.1
Coordinates 2112056..2112340 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE52_RS10085 2107364..2107795 - 432 WP_000152305.1 peroxiredoxin OsmC -
HPE52_RS10090 2108140..2108355 + 216 WP_000495766.1 biofilm-dependent modulation protein -
HPE52_RS10095 2108457..2108594 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HPE52_RS10100 2108751..2110448 + 1698 WP_000433460.1 malate dehydrogenase -
HPE52_RS10105 2110582..2111592 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
HPE52_RS10110 2111778..2112056 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPE52_RS10115 2112056..2112340 + 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HPE52_RS10120 2112569..2113222 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
HPE52_RS10125 2113215..2114099 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
HPE52_RS10130 2114112..2117159 - 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T159419 WP_000605675.1 NZ_CP054345:2111778-2112056 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T159419 NZ_CP070045:c1311762-1311655 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT159419 WP_000781370.1 NZ_CP054345:2112056-2112340 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT159419 NZ_CP070045:1311815-1311876 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CUG6

References