Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 534742..535322 Replicon chromosome
Accession NZ_CP054306
Organism Synechocystis sp. PCC 7338

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag HTZ78_RS02570 Protein ID WP_223342044.1
Coordinates 535029..535322 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HTZ78_RS02565 Protein ID WP_249213972.1
Coordinates 534742..534957 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTZ78_RS02545 (HTZ78_02540) 530103..531701 + 1599 WP_212718770.1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase -
HTZ78_RS02550 (HTZ78_02545) 531766..531999 + 234 WP_010873234.1 preprotein translocase subunit SecG -
HTZ78_RS02555 (HTZ78_02550) 532126..532911 + 786 WP_212718771.1 hypothetical protein -
HTZ78_RS02560 (HTZ78_02555) 533072..534382 - 1311 WP_212718773.1 dihydrolipoamide acetyltransferase family protein -
HTZ78_RS02565 (HTZ78_02560) 534742..534957 - 216 WP_249213972.1 HigA family addiction module antitoxin Antitoxin
HTZ78_RS02570 (HTZ78_02565) 535029..535322 - 294 WP_223342044.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HTZ78_RS02575 (HTZ78_02575) 535484..537145 - 1662 Protein_507 bifunctional serine/threonine-protein kinase/formylglycine-generating enzyme family protein -
HTZ78_RS02580 (HTZ78_02580) 537327..537965 + 639 WP_190596904.1 DUF3318 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(21-96)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-68)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11100.53 Da        Isoelectric Point: 9.7333

>T159400 WP_223342044.1 NZ_CP054306:c535322-535029 [Synechocystis sp. PCC 7338]
MITSFGNQATADLFNGINSRNSRRIPSEITQKALNKLDILNAVEKLEELNSPPGNRLEALKGNLKGFYSIRINNQWRIIF
QWQNGNVSQVQIIDYHD

Download         Length: 294 bp

>T159400 NZ_CP070041:2088309-2088686 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8251.50 Da        Isoelectric Point: 4.8537

>AT159400 WP_249213972.1 NZ_CP054306:c534957-534742 [Synechocystis sp. PCC 7338]
MNITQETLATYLNISVKQINEIIQEKNEITPKIAWLLAQAFDTTPQFWMNLQTNYDLALNKPQETKQAIKV

Download         Length: 216 bp

>AT159400 NZ_CP070041:2087888-2088262 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References