Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1391897..1392672 Replicon chromosome
Accession NZ_CP054285
Organism Klebsiella pneumoniae strain IDR1800050501-01-02

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag HS091_RS06775 Protein ID WP_004150910.1
Coordinates 1392187..1392672 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag HS091_RS06770 Protein ID WP_004150912.1
Coordinates 1391897..1392190 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HS091_RS06750 1387105..1387707 - 603 WP_002916735.1 short chain dehydrogenase -
HS091_RS06755 1387805..1388716 + 912 WP_135676418.1 LysR family transcriptional regulator -
HS091_RS06760 1388717..1389865 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
HS091_RS06765 1389876..1391252 - 1377 WP_004217775.1 cystathionine beta-synthase -
HS091_RS06770 1391897..1392190 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
HS091_RS06775 1392187..1392672 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
HS091_RS06780 1393376..1393969 + 594 WP_004188553.1 hypothetical protein -
HS091_RS06785 1394066..1394282 + 217 Protein_1311 transposase -
HS091_RS06795 1394960..1395673 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1394066..1394218 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T159336 WP_004150910.1 NZ_CP054285:1392187-1392672 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T159336 NZ_CP070015:c34249-34147 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT159336 WP_004150912.1 NZ_CP054285:1391897-1392190 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT159336 NZ_CP070015:34140-34285 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References