Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 978632..979278 Replicon chromosome
Accession NZ_CP054285
Organism Klebsiella pneumoniae strain IDR1800050501-01-02

Toxin (Protein)


Gene name higB Uniprot ID A0A483JFR4
Locus tag HS091_RS04545 Protein ID WP_004188313.1
Coordinates 978632..978979 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A483GM64
Locus tag HS091_RS04550 Protein ID WP_004188315.1
Coordinates 978979..979278 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HS091_RS04535 974558..975991 + 1434 WP_002920564.1 glycogen synthase GlgA -
HS091_RS04540 976009..978456 + 2448 WP_002920561.1 glycogen phosphorylase -
HS091_RS04545 978632..978979 + 348 WP_004188313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HS091_RS04550 978979..979278 + 300 WP_004188315.1 XRE family transcriptional regulator Antitoxin
HS091_RS04555 979341..980849 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
HS091_RS04560 981054..981383 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
HS091_RS04565 981434..982264 + 831 WP_004188317.1 rhomboid family intramembrane serine protease GlpG -
HS091_RS04570 982314..983072 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-78)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13548.57 Da        Isoelectric Point: 6.2327

>T159335 WP_004188313.1 NZ_CP054285:978632-978979 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T159335 NZ_CP070012:c5796-5545 [Escherichia coli]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATTACATTGTATGATGCCGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10873.64 Da        Isoelectric Point: 10.1464

>AT159335 WP_004188315.1 NZ_CP054285:978979-979278 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAAWG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT159335 NZ_CP070012:c5558-5331 [Escherichia coli]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGCAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483JFR4

Antitoxin

Source ID Structure
AlphaFold DB A0A483GM64

References