Detailed information of TA system TA159280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2403755..2404383
• Replicon: chromosome
• Accession: NZ_CP054277
• Organism: Serratia marcescens strain Byron

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: HS042_RS11355
• Protein ID: WP_041922289.1
• Coordinates: 2403755..2404045 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8B4GQY7
• Locus tag: HS042_RS11360
• Protein ID: WP_015379150.1
• Coordinates: 2404060..2404383 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HS042_RS11345	2400169..2402190	+	2022	WP_015379147.1	NADPH-dependent 2,4-dienoyl-CoA reductase	-
HS042_RS11350	2402385..2403524	-	1140	WP_015379148.1	23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG	-
HS042_RS11355	2403755..2404045	+	291	WP_041922289.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HS042_RS11360	2404060..2404383	+	324	WP_015379150.1	HigA family addiction module antidote protein	Antitoxin
HS042_RS11365	2404376..2404888	+	513	WP_015379151.1	M48 family metallopeptidase	-
HS042_RS11370	2404938..2405918	+	981	WP_004937152.1	Gfo/Idh/MocA family oxidoreductase	-
HS042_RS11375	2405920..2406651	+	732	WP_015379152.1	glutamine amidotransferase	-
HS042_RS11380	2406907..2407872	+	966	WP_049241556.1	TerC family protein	-
HS042_RS11385	2408135..2409370	+	1236	WP_015379154.1	serine/threonine transporter SstT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-94)

Antitoxin

• Cro/C1-type helix-turn-helix domain (24-71)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11608.26 Da
• Isoelectric Point: 10.0176

>T159280 WP_041922289.1 NZ_CP054277:2403755-2404045 [Serratia marcescens]
MIKSFRDRYLEQFYLEGKRSRLIPGVLERQLARKLDILAAAQQERDLHHPTGNYYKRLSGPFQGWSSLHVNMHWRLMFQW
RHDAAEKIYLDPHQDT

Nucleotide

• Length: 291 bp

>T159280 NZ_CP054277:2403755-2404045 [Serratia marcescens]
ATGATTAAATCTTTCCGCGATCGCTATCTGGAGCAGTTCTATCTGGAAGGCAAACGCAGCCGTCTGATCCCCGGCGTGCT
CGAGCGGCAGTTGGCCAGAAAGCTCGATATATTGGCCGCCGCGCAGCAAGAGCGTGATTTGCATCACCCCACGGGTAACT
ATTACAAGCGGCTATCCGGGCCATTTCAGGGATGGTCAAGTCTGCACGTCAATATGCACTGGCGGCTGATGTTCCAGTGG
CGGCATGATGCCGCTGAAAAAATTTACCTCGATCCTCACCAAGATACCTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12141.78 Da
• Isoelectric Point: 6.2285

>AT159280 WP_015379150.1 NZ_CP054277:2404060-2404383 [Serratia marcescens]
MLETTTREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQADAQRVRLRPIKEILGRNITHA

Nucleotide

• Length: 324 bp

>AT159280 NZ_CP054277:2404060-2404383 [Serratia marcescens]
ATGTTGGAAACCACGACTCGCGAACCCACCACGGTGGGGGAAGTGCTGCAGGAAGAGTATTTAACGCCGTTGGGCATCGG
CCAGGAAGAACTGGCGAAGGTACTGGGCGTCACCCGTGCCACTGTTAACCGCCTGTGCAACGGGCATCGACGCATGAGCG
TTGCCGAGGCCAACCTGTTTGCCGACCTGTTCGAAACGACCGCCGACTTTTGGCTAAACCTGCAGGCGGCACACGATCGC
TGGGAAGCCAGACAGGCCGATGCGCAACGTGTGCGGCTGCGGCCAATCAAAGAAATACTGGGACGCAATATCACTCATGC
ATGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GQY7