Detailed information of TA system TA159278

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2077147..2077799
• Replicon: chromosome
• Accession: NZ_CP054277
• Organism: Serratia marcescens strain Byron

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: HS042_RS09845
• Protein ID: WP_160125901.1
• Coordinates: 2077147..2077491 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A086GAN0
• Locus tag: HS042_RS09850
• Protein ID: WP_004931828.1
• Coordinates: 2077497..2077799 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HS042_RS09835	2073488..2075746	-	2259	WP_044030593.1	molybdopterin guanine dinucleotide-containing S/N-oxide reductase	-
HS042_RS09840	2075968..2076987	+	1020	WP_160125900.1	HTH-type transcriptional regulator GalR	-
HS042_RS09845	2077147..2077491	+	345	WP_160125901.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HS042_RS09850	2077497..2077799	+	303	WP_004931828.1	helix-turn-helix transcriptional regulator	Antitoxin
HS042_RS09855	2077827..2079089	-	1263	WP_021505676.1	diaminopimelate decarboxylase	-
HS042_RS09860	2079223..2080146	+	924	WP_160125902.1	LysR family transcriptional regulator	-
HS042_RS09865	2080174..2081082	-	909	WP_015378928.1	LysR family transcriptional regulator	-
HS042_RS09870	2081191..2082075	+	885	WP_004931820.1	MBL fold metallo-hydrolase	-
HS042_RS09875	2082144..2082791	+	648	WP_015378930.1	DsbA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-85)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13482.58 Da
• Isoelectric Point: 10.8652

>T159278 WP_160125901.1 NZ_CP054277:2077147-2077491 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLARPHADTLHFSDAVRQLKELRIQHRRRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Nucleotide

• Length: 345 bp

>T159278 NZ_CP069994:c4032714-4032346 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11080.97 Da
• Isoelectric Point: 10.1998

>AT159278 WP_004931828.1 NZ_CP054277:2077497-2077799 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT159278 NZ_CP069994:c4032932-4032711 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A086GAN0