Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 352889..353535 Replicon chromosome
Accession NZ_CP054268
Organism Klebsiella pneumoniae strain 39427

Toxin (Protein)


Gene name higB Uniprot ID W8UNE1
Locus tag HPS02_RS03370 Protein ID WP_002920560.1
Coordinates 352889..353236 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag HPS02_RS03375 Protein ID WP_002920557.1
Coordinates 353236..353535 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPS02_RS03360 348815..350248 + 1434 WP_002920564.1 glycogen synthase GlgA -
HPS02_RS03365 350266..352713 + 2448 WP_002920561.1 glycogen phosphorylase -
HPS02_RS03370 352889..353236 + 348 WP_002920560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPS02_RS03375 353236..353535 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
HPS02_RS03380 353598..355106 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
HPS02_RS03385 355311..355640 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
HPS02_RS03390 355691..356521 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
HPS02_RS03395 356571..357329 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13502.56 Da        Isoelectric Point: 6.2300

>T159241 WP_002920560.1 NZ_CP054268:352889-353236 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T159241 NZ_CP069990:1599215-1599322 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT159241 WP_002920557.1 NZ_CP054268:353236-353535 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT159241 NZ_CP069990:c1599162-1599101 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CBY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References