Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4750096..4750796 Replicon chromosome
Accession NZ_CP054264
Organism Pseudomonas putida strain A0_F0_I1

Toxin (Protein)


Gene name mqsR Uniprot ID Q88F93
Locus tag HG554_RS21910 Protein ID WP_010954960.1
Coordinates 4750500..4750796 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID I7AUJ7
Locus tag HG554_RS21905 Protein ID WP_003254235.1
Coordinates 4750096..4750497 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG554_RS21885 (HG554_21880) 4745230..4746051 - 822 WP_010954957.1 transporter substrate-binding domain-containing protein -
HG554_RS21890 (HG554_21885) 4746127..4747056 - 930 WP_010954958.1 FAD-binding protein -
HG554_RS21895 (HG554_21890) 4747057..4747806 - 750 WP_003254232.1 electron transfer flavoprotein subunit beta/FixA family protein -
HG554_RS21900 (HG554_21895) 4748342..4750024 + 1683 WP_010954959.1 electron transfer flavoprotein-ubiquinone oxidoreductase -
HG554_RS21905 (HG554_21900) 4750096..4750497 - 402 WP_003254235.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
HG554_RS21910 (HG554_21905) 4750500..4750796 - 297 WP_010954960.1 type II toxin-antitoxin system MqsR family toxin Toxin
HG554_RS21915 (HG554_21910) 4750891..4752216 - 1326 WP_010954961.1 MFS transporter -
HG554_RS21920 (HG554_21915) 4752289..4752768 - 480 WP_010954962.1 hypothetical protein -
HG554_RS21925 (HG554_21920) 4752937..4753413 - 477 WP_010954963.1 sigma-70 family RNA polymerase sigma factor -
HG554_RS21930 (HG554_21925) 4753626..4754804 + 1179 WP_010954964.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(6-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(74-109)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11133.22 Da        Isoelectric Point: 10.2271

>T159238 WP_010954960.1 NZ_CP054264:c4750796-4750500 [Pseudomonas putida]
MEKRMPHCPLERVKALAAARRIRPTGAALKGAKALGMDFPGMLEVITSLKRTDFYKSMTSHIDHRVWQDVYRPLTAIGYV
YLKLSVVDDVLIVSFKEL

Download         Length: 297 bp

>T159238 NZ_CP069990:1002610-1002712 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14684.76 Da        Isoelectric Point: 4.9531

>AT159238 WP_003254235.1 NZ_CP054264:c4750497-4750096 [Pseudomonas putida]
MRCPICGGSELAPDIQGMPYSYKGEMTVIPEVSGDYCSACGECVLSHDEAMRVSHLMTAFERQVNANVVDPSFIASIRRK
FDLDQREAGEIFGGGVNAFSRYENGKTTPPVALVKLLKLLDRHPELFEEVRTA

Download         Length: 402 bp

>AT159238 NZ_CP069990:c1002750-1002482 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q88F93

Antitoxin

Source ID Structure
AlphaFold DB I7AUJ7

References