Detailed information of TA system TA159221

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1779481..1780181
• Replicon: chromosome
• Accession: NZ_CP054257
• Organism: Treponema parvum strain ATCC 700773

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: HRI96_RS07870
• Protein ID: WP_210116836.1
• Coordinates: 1779481..1779792 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HRI96_RS07875
• Protein ID: WP_256729188.1
• Coordinates: 1779876..1780181 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRI96_RS07850 (HRI96_07875)	1775442..1776437	+	996	WP_210116832.1	alpha/beta hydrolase	-
HRI96_RS07855 (HRI96_07880)	1776474..1778096	-	1623	WP_210116833.1	tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))- methylthiotransferase MtaB	-
HRI96_RS07860 (HRI96_07885)	1778096..1778734	-	639	WP_210116834.1	tetratricopeptide repeat protein	-
HRI96_RS07865 (HRI96_07890)	1778841..1779200	-	360	WP_210116835.1	polymer-forming cytoskeletal protein	-
HRI96_RS07870 (HRI96_07895)	1779481..1779792	+	312	WP_210116836.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HRI96_RS07875 (HRI96_07900)	1779876..1780181	+	306	WP_256729188.1	NadS family protein	Antitoxin
HRI96_RS07880 (HRI96_07905)	1780503..1781528	+	1026	WP_210116837.1	phosphate acetyltransferase	-
HRI96_RS07885 (HRI96_07910)	1781584..1781757	-	174	WP_210116838.1	hypothetical protein	-
HRI96_RS07890 (HRI96_07915)	1781813..1784431	+	2619	WP_210116839.1	ATP-dependent RNA helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-100)

Antitoxin

• Cro/C1-type helix-turn-helix domain (42-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12016.22 Da
• Isoelectric Point: 10.3597

>T159221 WP_210116836.1 NZ_CP054257:1779481-1779792 [Treponema parvum]
MELIETSIFKKRIDQLLDGITYAQFREYLVCNPLRGKLIKHGGGIRKIRWKTKYSGKSSGIRIIYFIKSNTKIYLLYCYA
KNQAGDLTREQIKDLALLVKDLQ

Nucleotide

• Length: 312 bp

>T159221 NZ_CP069980:c3292251-3292033 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11498.41 Da
• Isoelectric Point: 10.2428

>AT159221 WP_256729188.1 NZ_CP054257:1779876-1780181 [Treponema parvum]
MLKKRMPNEMFDELKQSVKEAISIEEGKMKPSRVFHIEPLDISEIRNKTNKTQEEFAAMLNVSVGTLRNWEQGRRKPAGA
ALSLLKIVSADPQYVKNVLVT

Nucleotide

• Length: 306 bp

>AT159221 NZ_CP069980:c3292651-3292277 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG