Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1244789..1245382 Replicon chromosome
Accession NZ_CP054257
Organism Treponema parvum strain ATCC 700773

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRI96_RS05570 Protein ID WP_210118512.1
Coordinates 1245101..1245382 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRI96_RS05565 Protein ID WP_210118511.1
Coordinates 1244789..1245088 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRI96_RS05530 (HRI96_05550) 1240134..1240727 + 594 WP_210118504.1 hypothetical protein -
HRI96_RS05535 (HRI96_05555) 1240700..1241164 + 465 WP_210118505.1 hypothetical protein -
HRI96_RS05540 (HRI96_05560) 1242022..1242897 + 876 WP_210118506.1 SUMF1/EgtB/PvdO family nonheme iron enzyme -
HRI96_RS05545 (HRI96_05565) 1242887..1243171 + 285 WP_210118507.1 hypothetical protein -
HRI96_RS05550 (HRI96_05570) 1243146..1243622 + 477 WP_210118508.1 hypothetical protein -
HRI96_RS05555 (HRI96_05575) 1243924..1244136 + 213 WP_210118509.1 DUF2281 domain-containing protein -
HRI96_RS05560 (HRI96_05580) 1244136..1244651 + 516 WP_210118510.1 type II toxin-antitoxin system VapC family toxin -
HRI96_RS05565 (HRI96_05585) 1244789..1245088 - 300 WP_210118511.1 HigA family addiction module antitoxin Antitoxin
HRI96_RS05570 (HRI96_05590) 1245101..1245382 - 282 WP_210118512.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRI96_RS05575 (HRI96_05595) 1245597..1246820 + 1224 WP_210118513.1 hypothetical protein -
HRI96_RS05580 (HRI96_05600) 1246920..1250096 + 3177 WP_210118514.1 isoleucine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10968.57 Da        Isoelectric Point: 7.8787

>T159219 WP_210118512.1 NZ_CP054257:c1245382-1245101 [Treponema parvum]
MIKTFGDSETEKLWNGKKSARLPPDIHKRAFTKLLIINSAECEDDLKIPPGNKFEHLLGDLKDYCSIRINDQWRIRFKFQ
SNEAYEVKIVDYH

Download         Length: 282 bp

>T159219 NZ_CP069980:c2774753-2774601 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11372.27 Da        Isoelectric Point: 8.9490

>AT159219 WP_210118511.1 NZ_CP054257:c1245088-1244789 [Treponema parvum]
MDEKFELPKIGDIIREEFLEPLGITPYRLAKDLGVSTSSVLDLVHGKRKISVEMALRLSKYFGTSSKFWLNMQNELDLRE
AKEKLKSDLEKIPSCRKTA

Download         Length: 300 bp

>AT159219 NZ_CP069980:2774802-2774859 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References