Detailed information of TA system TA159163

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1196025..1196283
• Replicon: chromosome
• Accession: NZ_CP054236
• Organism: Escherichia coli strain EcPF5

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HR070_RS05800
• Protein ID: WP_001181672.1
• Coordinates: 1196025..1196234 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1196226..1196283 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HR070_RS05780	1191270..1191983	-	714	WP_001102391.1	acidic protein MsyB	-
HR070_RS05785	1192009..1192413	-	405	WP_000843687.1	DUF2541 family protein	-
HR070_RS05790	1192785..1194701	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HR070_RS05795	1194790..1195920	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HR070_RS05800	1196025..1196234	-	210	WP_001181672.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	1196226..1196283	+	58	-	-	Antitoxin
HR070_RS05805	1196792..1197553	+	762	WP_001274832.1	hypothetical protein	-
HR070_RS05810	1197573..1199066	+	1494	WP_001443162.1	sulfatase-like hydrolase/transferase	-
HR070_RS05815	1199195..1200454	+	1260	WP_000494928.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7757.25 Da
• Isoelectric Point: 9.3680

>T159163 WP_001181672.1 NZ_CP054236:c1196234-1196025 [Escherichia coli]
MQNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T159163 NZ_CP069973:1375630-1375941 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT159163 NZ_CP054236:1196226-1196283 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin