Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-agrB/Ldr(toxin)
Location 4918541..4918762 Replicon chromosome
Accession NZ_CP054232
Organism Escherichia coli strain EcPF7

Toxin (Protein)


Gene name ldrD Uniprot ID A0A1U9U3P9
Locus tag HR071_RS23705 Protein ID WP_001531632.1
Coordinates 4918541..4918648 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 4918696..4918762 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HR071_RS23680 4914385..4915467 + 1083 WP_000804726.1 peptide chain release factor 1 -
HR071_RS23685 4915467..4916300 + 834 WP_000456450.1 peptide chain release factor N(5)-glutamine methyltransferase -
HR071_RS23690 4916297..4916689 + 393 WP_000200375.1 invasion regulator SirB2 -
HR071_RS23695 4916693..4917502 + 810 WP_001257044.1 invasion regulator SirB1 -
HR071_RS23700 4917538..4918392 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
HR071_RS23705 4918541..4918648 - 108 WP_001531632.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 4918696..4918762 + 67 NuclAT_10 - Antitoxin
- 4918696..4918762 + 67 NuclAT_10 - Antitoxin
- 4918696..4918762 + 67 NuclAT_10 - Antitoxin
- 4918696..4918762 + 67 NuclAT_10 - Antitoxin
- 4918696..4918762 + 67 NuclAT_5 - Antitoxin
- 4918696..4918762 + 67 NuclAT_5 - Antitoxin
- 4918696..4918762 + 67 NuclAT_5 - Antitoxin
- 4918696..4918762 + 67 NuclAT_5 - Antitoxin
- 4918696..4918762 + 67 NuclAT_6 - Antitoxin
- 4918696..4918762 + 67 NuclAT_6 - Antitoxin
- 4918696..4918762 + 67 NuclAT_6 - Antitoxin
- 4918696..4918762 + 67 NuclAT_6 - Antitoxin
- 4918696..4918762 + 67 NuclAT_7 - Antitoxin
- 4918696..4918762 + 67 NuclAT_7 - Antitoxin
- 4918696..4918762 + 67 NuclAT_7 - Antitoxin
- 4918696..4918762 + 67 NuclAT_7 - Antitoxin
- 4918696..4918762 + 67 NuclAT_8 - Antitoxin
- 4918696..4918762 + 67 NuclAT_8 - Antitoxin
- 4918696..4918762 + 67 NuclAT_8 - Antitoxin
- 4918696..4918762 + 67 NuclAT_8 - Antitoxin
- 4918696..4918762 + 67 NuclAT_9 - Antitoxin
- 4918696..4918762 + 67 NuclAT_9 - Antitoxin
- 4918696..4918762 + 67 NuclAT_9 - Antitoxin
- 4918696..4918762 + 67 NuclAT_9 - Antitoxin
- 4918698..4918761 + 64 NuclAT_14 - -
- 4918698..4918761 + 64 NuclAT_14 - -
- 4918698..4918761 + 64 NuclAT_14 - -
- 4918698..4918761 + 64 NuclAT_14 - -
- 4918698..4918761 + 64 NuclAT_15 - -
- 4918698..4918761 + 64 NuclAT_15 - -
- 4918698..4918761 + 64 NuclAT_15 - -
- 4918698..4918761 + 64 NuclAT_15 - -
- 4918698..4918761 + 64 NuclAT_16 - -
- 4918698..4918761 + 64 NuclAT_16 - -
- 4918698..4918761 + 64 NuclAT_16 - -
- 4918698..4918761 + 64 NuclAT_16 - -
- 4918698..4918761 + 64 NuclAT_17 - -
- 4918698..4918761 + 64 NuclAT_17 - -
- 4918698..4918761 + 64 NuclAT_17 - -
- 4918698..4918761 + 64 NuclAT_17 - -
- 4918698..4918761 + 64 NuclAT_18 - -
- 4918698..4918761 + 64 NuclAT_18 - -
- 4918698..4918761 + 64 NuclAT_18 - -
- 4918698..4918761 + 64 NuclAT_18 - -
- 4918698..4918761 + 64 NuclAT_19 - -
- 4918698..4918761 + 64 NuclAT_19 - -
- 4918698..4918761 + 64 NuclAT_19 - -
- 4918698..4918761 + 64 NuclAT_19 - -
- 4918698..4918763 + 66 NuclAT_20 - -
- 4918698..4918763 + 66 NuclAT_20 - -
- 4918698..4918763 + 66 NuclAT_20 - -
- 4918698..4918763 + 66 NuclAT_20 - -
- 4918698..4918763 + 66 NuclAT_21 - -
- 4918698..4918763 + 66 NuclAT_21 - -
- 4918698..4918763 + 66 NuclAT_21 - -
- 4918698..4918763 + 66 NuclAT_21 - -
- 4918698..4918763 + 66 NuclAT_22 - -
- 4918698..4918763 + 66 NuclAT_22 - -
- 4918698..4918763 + 66 NuclAT_22 - -
- 4918698..4918763 + 66 NuclAT_22 - -
- 4918698..4918763 + 66 NuclAT_23 - -
- 4918698..4918763 + 66 NuclAT_23 - -
- 4918698..4918763 + 66 NuclAT_23 - -
- 4918698..4918763 + 66 NuclAT_23 - -
- 4918698..4918763 + 66 NuclAT_24 - -
- 4918698..4918763 + 66 NuclAT_24 - -
- 4918698..4918763 + 66 NuclAT_24 - -
- 4918698..4918763 + 66 NuclAT_24 - -
- 4918698..4918763 + 66 NuclAT_25 - -
- 4918698..4918763 + 66 NuclAT_25 - -
- 4918698..4918763 + 66 NuclAT_25 - -
- 4918698..4918763 + 66 NuclAT_25 - -
HR071_RS23710 4919053..4920153 - 1101 WP_000063608.1 sodium-potassium/proton antiporter ChaA -
HR071_RS23715 4920423..4920662 + 240 WP_000120702.1 putative cation transport regulator ChaB -
HR071_RS23720 4920811..4921506 + 696 WP_001295621.1 glutathione-specific gamma-glutamylcyclotransferase -
HR071_RS23725 4921550..4921903 - 354 WP_001169659.1 DsrE/F sulfur relay family protein YchN -
HR071_RS23730 4922088..4923482 + 1395 WP_000086187.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4040.89 Da        Isoelectric Point: 12.5163

>T159152 WP_001531632.1 NZ_CP054232:c4918648-4918541 [Escherichia coli]
MTLAQFAMIFWHNLAAPILAGIITAVIVSWWRNRK

Download         Length: 108 bp

>T159152 NZ_CP069971:c11405-11058 [Escherichia coli]
ATGTGGACGGTACTTTTTAGCCAGCGATTTGACGACTGGCTAAATGAGCAAGAAGACGCTCTTCAGGAAAAGGTTTTGGC
TGATTTGAAAAAGCTACAGGTTTACGGACCTGAGTTACCCAGGCCATATGCCGATACCGTAAAAGGTTCTCGGTACAAAA
ATATGAAAGAGCTTCGCGTTCAGTTTTCTGGCCGTCCGATAAGAGCCTTTTATGCGTTCGATCCGATTCGCCGGGCCATC
GTTCTTTGTGCAGGAGACAAAAGTAACGATAAACGGTTTTATGAAAAACTGGTGCGTATAGCTGAGGATGAGTTTGCAGC
ACATCTGAACACACTGGAGAGCAAGTAA

Antitoxin


Download         Length: 67 bp

>AT159152 NZ_CP054232:4918696-4918762 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9U3P9

Antitoxin

Download structure file

References