Detailed information of TA system TA159137

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2448607..2448829
• Replicon: chromosome
• Accession: NZ_CP054232
• Organism: Escherichia coli strain EcPF7

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: HR071_RS11830
• Protein ID: WP_001295224.1
• Coordinates: 2448607..2448714 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2448763..2448829 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HR071_RS11800	2443659..2443847	-	189	WP_001063314.1	YhjR family protein	-
HR071_RS11805	2444120..2445691	+	1572	WP_001204941.1	cellulose biosynthesis protein BcsE	-
HR071_RS11810	2445688..2445879	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
HR071_RS11815	2445876..2447555	+	1680	WP_000191553.1	cellulose biosynthesis protein BcsG	-
HR071_RS11820	2447641..2447748	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
HR071_RS11825	2448124..2448231	-	108	WP_000170745.1	type I toxin-antitoxin system toxin Ldr family protein	-
HR071_RS11830	2448607..2448714	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2448763..2448829	+	67	-	-	Antitoxin
HR071_RS11835	2449190..2450461	+	1272	WP_001296513.1	amino acid permease	-
HR071_RS11840	2450491..2451495	-	1005	WP_000103571.1	dipeptide ABC transporter ATP-binding subunit DppF	-
HR071_RS11845	2451492..2452475	-	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
HR071_RS11850	2452486..2453388	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T159137 WP_001295224.1 NZ_CP054232:c2448714-2448607 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T159137 NZ_CP069967:30340-30756 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCAACCAGCGCATTGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGCC
CGAAGGCCTCCCCGCGCCACATTGAGCTGGTTGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCTATCGCGGCCGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTTAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT159137 NZ_CP054232:2448763-2448829 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin