Detailed information of TA system TA158961

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 691545..691803
• Replicon: chromosome
• Accession: NZ_CP054214
• Organism: Escherichia coli strain EcPF40

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HR076_RS03320
• Protein ID: WP_001181672.1
• Coordinates: 691545..691754 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	691746..691803 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HR076_RS03300	686790..687503	-	714	WP_001102391.1	acidic protein MsyB	-
HR076_RS03305	687529..687933	-	405	WP_000843687.1	DUF2541 family protein	-
HR076_RS03310	688305..690221	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HR076_RS03315	690310..691440	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HR076_RS03320	691545..691754	-	210	WP_001181672.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	691746..691803	+	58	-	-	Antitoxin
HR076_RS03325	692312..693073	+	762	WP_001274832.1	hypothetical protein	-
HR076_RS03330	693093..694586	+	1494	WP_001774152.1	sulfatase-like hydrolase/transferase	-
HR076_RS03335	694715..695974	+	1260	WP_000494929.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7757.25 Da
• Isoelectric Point: 9.3680

>T158961 WP_001181672.1 NZ_CP054214:c691754-691545 [Escherichia coli]
MQNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T158961 NZ_CP069894:118036-118314 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGTGCATTCGTGAGTACATTGCGGAGCAGAACCTGATAGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAACCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGAGTATTGCATACTGTACAGAAGTGGCCATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT158961 NZ_CP054214:691746-691803 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin