Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1123209..1123770 Replicon chromosome
Accession NZ_CP054198
Organism Glaesserella parasuis strain YHP170504

Toxin (Protein)


Gene name higB Uniprot ID A0A143CE91
Locus tag HQ939_RS05675 Protein ID WP_005712614.1
Coordinates 1123492..1123770 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag HQ939_RS05670 Protein ID WP_005712616.1
Coordinates 1123209..1123481 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ939_RS05655 1119757..1120275 + 519 WP_021110692.1 single-stranded DNA-binding protein -
HQ939_RS05660 1120428..1121915 - 1488 WP_062923800.1 DUF853 domain-containing protein -
HQ939_RS05665 1121925..1123145 - 1221 WP_075606453.1 ATP-dependent RNA helicase RhlB -
HQ939_RS05670 1123209..1123481 - 273 WP_005712616.1 HigA family addiction module antidote protein Antitoxin
HQ939_RS05675 1123492..1123770 - 279 WP_005712614.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HQ939_RS05680 1123919..1124929 + 1011 WP_075606452.1 ornithine carbamoyltransferase -
HQ939_RS05685 1125282..1125623 - 342 WP_075606451.1 hypothetical protein -
HQ939_RS05690 1125628..1126311 - 684 WP_075606450.1 hypothetical protein -
HQ939_RS05695 1126656..1127918 + 1263 WP_021113526.1 serine hydroxymethyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10326.71 Da        Isoelectric Point: 10.0505

>T158945 WP_005712614.1 NZ_CP054198:c1123770-1123492 [Glaesserella parasuis]
MIISFKHKGLKLFFETGSTAGIQANHASKLAFQLATLNQAKSALDMNAPSWNLHQLQGNLAGHWSIKVSGNWRLTFKFQN
GHAEVVDYQDYH

Download         Length: 279 bp

>T158945 NZ_CP069893:c2203692-2203585 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATAGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10314.06 Da        Isoelectric Point: 9.8982

>AT158945 WP_005712616.1 NZ_CP054198:c1123481-1123209 [Glaesserella parasuis]
MKMYNPAHPGLILREYIEGYNVTEVAKRLGVTRVTLSRILNGKAAISPEMALRLSQLLKTSPELWLGLQSQYDLWQLEQR
PSFNIQPLFA

Download         Length: 273 bp

>AT158945 NZ_CP069893:2203740-2203806 [Escherichia coli]
GGTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143CE91

Antitoxin

Source ID Structure

References