Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3574157..3574850 Replicon chromosome
Accession NZ_CP054169
Organism Escherichia coli strain STO_Bone1B

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag HRS04_RS18200 Protein ID WP_000415585.1
Coordinates 3574554..3574850 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HRS04_RS18195 Protein ID WP_000650107.1
Coordinates 3574157..3574552 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS04_RS18185 (3570021) 3570021..3572279 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
HRS04_RS18190 (3572417) 3572417..3574024 - 1608 WP_001375094.1 ABC transporter substrate-binding protein -
HRS04_RS18195 (3574157) 3574157..3574552 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HRS04_RS18200 (3574554) 3574554..3574850 - 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
HRS04_RS18205 (3575055) 3575055..3575537 - 483 WP_000183505.1 GyrI-like domain-containing protein -
HRS04_RS18210 (3575590) 3575590..3575982 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HRS04_RS18215 (3576134) 3576134..3576793 + 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
HRS04_RS18220 (3576790) 3576790..3578139 + 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
HRS04_RS18225 (3578185) 3578185..3578517 - 333 WP_000914690.1 DUF2645 family protein -
HRS04_RS18230 (3578524) 3578524..3579234 - 711 WP_000834030.1 hypothetical protein -
HRS04_RS18235 (3579237) 3579237..3579716 - 480 WP_000065332.1 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T158879 WP_000415585.1 NZ_CP054169:c3574850-3574554 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T158879 NZ_CP069873:2196972-2197256 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT158879 WP_000650107.1 NZ_CP054169:c3574552-3574157 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT158879 NZ_CP069873:2196740-2196982 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGGTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References