Detailed information of TA system TA158854

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 350594..350852
• Replicon: chromosome
• Accession: NZ_CP054169
• Organism: Escherichia coli strain STO_Bone1B

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HRS04_RS02810
• Protein ID: WP_000809172.1
• Coordinates: 350594..350746 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	350795..350852 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRS04_RS02790	345835..346548	-	714	WP_001102385.1	acidic protein MsyB	-
HRS04_RS02795	346574..346978	-	405	WP_001584154.1	DUF2541 family protein	-
HRS04_RS02800	347355..349271	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HRS04_RS02805	349360..350490	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HRS04_RS02810	350594..350746	-	153	WP_000809172.1	type I toxin-antitoxin system toxin MokC	Toxin
-	350795..350852	+	58	-	-	Antitoxin
HRS04_RS02815	351332..352498	+	1167	WP_235245303.1	Na+/H+ antiporter NhaA	-
HRS04_RS02820	352564..353463	+	900	WP_001300855.1	transcriptional activator NhaR	-
HRS04_RS02825	353502..354461	-	960	Protein_352	fimbrial family protein	-
HRS04_RS02830	354474..355826	-	1353	Protein_353	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5529.62 Da
• Isoelectric Point: 7.1312

>T158854 WP_000809172.1 NZ_CP054169:c350746-350594 [Escherichia coli]
MKQHKAMIVALIVICITAVVAVLVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T158854 NZ_CP069865:1533389-1533853 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAACCCCATTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT158854 NZ_CP054169:350795-350852 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin