Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1678061..1678754 Replicon chromosome
Accession NZ_CP054161
Organism Escherichia coli strain STO_Bone2

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HRS05_RS07985 Protein ID WP_000415584.1
Coordinates 1678061..1678357 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HRS05_RS07990 Protein ID WP_000650107.1
Coordinates 1678359..1678754 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS05_RS07950 (1673149) 1673149..1673463 - 315 WP_000958598.1 putative quinol monooxygenase -
HRS05_RS07955 (1673494) 1673494..1674075 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HRS05_RS07960 (1674394) 1674394..1674726 + 333 WP_023149630.1 DUF2645 family protein -
HRS05_RS07965 (1674772) 1674772..1676121 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
HRS05_RS07970 (1676118) 1676118..1676777 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HRS05_RS07975 (1676929) 1676929..1677321 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HRS05_RS07980 (1677374) 1677374..1677856 + 483 WP_000183505.1 GyrI-like domain-containing protein -
HRS05_RS07985 (1678061) 1678061..1678357 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HRS05_RS07990 (1678359) 1678359..1678754 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HRS05_RS07995 (1678887) 1678887..1680494 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HRS05_RS08000 (1680632) 1680632..1682890 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T158817 WP_000415584.1 NZ_CP054161:1678061-1678357 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T158817 NZ_CP069851:3398069-3398251 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT158817 WP_000650107.1 NZ_CP054161:1678359-1678754 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT158817 NZ_CP069851:3398316-3398720 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References