Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3721429..3722088 Replicon chromosome
Accession NZ_CP054160
Organism Serratia fonticola strain HH13

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G9399_RS17115 Protein ID WP_173409016.1
Coordinates 3721735..3722088 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID U2NFA4
Locus tag G9399_RS17110 Protein ID WP_021180280.1
Coordinates 3721429..3721731 (-) Length 101 a.a.

Genomic Context

G9399_RS17090G9399_RS17095G9399_RS17100G9399_RS17105G9399_RS17110G9399_RS17115G9399_RS17120G9399_RS17125G9399_RS17130G9399_RS17135
Location: 3716756..3717925 (1170 bp)
Type: Others
Protein ID: WP_024528107.1
Location: 3717946..3718890 (945 bp)
Type: Others
Protein ID: WP_065683277.1
Location: 3718963..3720165 (1203 bp)
Type: Others
Protein ID: WP_173409018.1
Location: 3720425..3721285 (861 bp)
Type: Others
Protein ID: WP_173409017.1
Location: 3721429..3721731 (303 bp)
Type: Antitoxin
Protein ID: WP_021180280.1
Location: 3721735..3722088 (354 bp)
Type: Toxin
Protein ID: WP_173409016.1
Location: 3722346..3723533 (1188 bp)
Type: Others
Protein ID: WP_024528102.1
Location: 3723705..3724421 (717 bp)
Type: Others
Protein ID: WP_065683272.1
Location: 3724418..3725293 (876 bp)
Type: Others
Protein ID: WP_024528101.1
Location: 3725290..3726576 (1287 bp)
Type: Others
Protein ID: WP_024528100.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
G9399_RS17090 (G9399_09375)3716756..3717925+1170WP_024528107.1flavin-dependent monooxygenase-
G9399_RS17095 (G9399_09370)3717946..3718890+945WP_065683277.1flavin reductase family protein-
G9399_RS17100 (G9399_09365)3718963..3720165-1203WP_173409018.1Bcr/CflA family multidrug efflux MFS transporter-
G9399_RS17105 (G9399_09360)3720425..3721285-861WP_173409017.1aldo/keto reductase family oxidoreductase-
G9399_RS17110 (G9399_09355)3721429..3721731-303WP_021180280.1XRE family transcriptional regulatorAntitoxin
G9399_RS17115 (G9399_09350)3721735..3722088-354WP_173409016.1type II toxin-antitoxin system RelE/ParE family toxinToxin
G9399_RS17120 (G9399_09345)3722346..3723533-1188WP_024528102.1sugar transporter-
G9399_RS17125 (G9399_09340)3723705..3724421-717WP_065683272.1ABC transporter ATP-binding protein-
G9399_RS17130 (G9399_09335)3724418..3725293-876WP_024528101.1ATP-binding cassette domain-containing protein-
G9399_RS17135 (G9399_09330)3725290..3726576-1287WP_024528100.1high-affinity branched-chain amino acid ABC transporter permease LivM-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13606.61 Da        Isoelectric Point: 9.9193

>T158808 WP_173409016.1 NZ_CP054160:c3722088-3721735 [Serratia fonticola]
VWEIKTTDMFDEWFSRLEDTDRASVLASLIVLREKGPQLPRPYADTVKGSRYSNMKELRVQSRGIPIRAFFAFDLRRRGI
LLCAGNKAGNEKRFYEVMIPIADRAFTQFLNTSENKE

Download         Length: 354 bp

>T158808 NZ_CP069847:2113886-2114104 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11022.78 Da        Isoelectric Point: 6.4749

>AT158808 WP_021180280.1 NZ_CP054160:c3721731-3721429 [Serratia fonticola]
MGRTLEQILAEEKPEVVASAERIAADTLLNIHLAELRERVQKTQVEMAQALGIKQPTVAGMEKPGRDLKLSSLKRYIEAA
GGKLRLDIELPDGSHYGFVI

Download         Length: 303 bp

>AT158808 NZ_CP069847:2113485-2113859 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBU2NFA4

References