Detailed information of TA system TA158769

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 4741559..4742064
• Replicon: chromosome
• Accession: NZ_CP054139
• Organism: Mucilaginibacter mali strain G2-14

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HQ865_RS20020
• Protein ID: WP_173416607.1
• Coordinates: 4741559..4741813 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HQ865_RS20025
• Protein ID: WP_173416608.1
• Coordinates: 4741810..4742064 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HQ865_RS20010	4739874..4740155	+	282	WP_173417862.1	DUF2752 domain-containing protein	-
HQ865_RS20015	4740167..4741480	-	1314	WP_173416606.1	hypothetical protein	-
HQ865_RS20020	4741559..4741813	-	255	WP_173416607.1	Txe/YoeB family addiction module toxin	Toxin
HQ865_RS20025	4741810..4742064	-	255	WP_173416608.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HQ865_RS20030	4742128..4742829	-	702	WP_173416609.1	hypothetical protein	-
HQ865_RS20035	4742881..4743432	-	552	WP_173416610.1	dihydrofolate reductase family protein	-
HQ865_RS20040	4743653..4746499	-	2847	WP_173416611.1	excinuclease ABC subunit UvrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10164.73 Da
• Isoelectric Point: 8.8643

>T158769 WP_173416607.1 NZ_CP054139:c4741813-4741559 [Mucilaginibacter mali]
MKIIFLDQGWEDYLYWQSTDKSILKKINSLIKEIERTPFEGSGKPEPLRHNLAGWWSRRINLEHRVVYKIDADSIIILQC
RYHY

Nucleotide

• Length: 255 bp

>T158769 NZ_CP069812:670009-670380 [Cupriavidus oxalaticus]
ATGATCCTGGTCGACACCTCGGTATGGATCGACCATCTGCGTACCGGCGACGCGGCACTAGCGGCTTTGCTCGACGCCAG
CCGGGTCCTGGTGCATCCGTTTGTGATCGGCGAGATCGCGCTGGGTAGCCTGCGGCAGCGGGGCGAGGTGCTGGGCGCTT
TGCGTGATTTGCCAGGCGCCGTCGTGGCGACGGACGACGAAGTCGACCGGATGATCGATGACCAGAAGTTGTACGGGATA
GGGATTGGCTACGTGGATGCGCATCTGCTGGCCGCCACCCGATTGACGCCCGGCAGTGCGCTATGGACGCGGGATCGTCG
CCTGCTCGCGGTCGCCGAGCATTTGGGGCTGGCCGCGCGGCCTGCGCATTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9527.74 Da
• Isoelectric Point: 5.1186

>AT158769 WP_173416608.1 NZ_CP054139:c4742064-4741810 [Mucilaginibacter mali]
MLTTTYTSFRQQLKSYLDKVRKSHTPLYVTSANGEDVVVLSKADYESMEETFYLLKSPANAARLLKGIEDYEKGLGTERS
LAEE

Nucleotide

• Length: 255 bp

>AT158769 NZ_CP069812:669815-670012 [Cupriavidus oxalaticus]
ATGCGCACCACGCTTGCCCTGGACGATGATTTGCTGCGCAAGGCCCAGGCCCTGACCGGCCTGTCCGAAAAATCCTCGCT
CGTGCGCGAAGCGCTGCGGGCACTGATCGAGCGCGAAAGCGCGCGCCGCCTGAGCCGTCTCGGCGGTACCGAACCCGACC
TGGAATCCGCGCCGCGCCGCCGCGCGGAGCCGGCATGA