Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4770488..4771087 Replicon chromosome
Accession NZ_CP054129
Organism Citrobacter portucalensis strain BY9F36

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRV88_RS22715 Protein ID WP_057066653.1
Coordinates 4770776..4771087 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRV88_RS22710 Protein ID WP_038635893.1
Coordinates 4770488..4770775 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRV88_RS22695 (HRV88_22630) 4767984..4768886 + 903 WP_003825273.1 formate dehydrogenase O subunit beta -
HRV88_RS22700 (HRV88_22635) 4768883..4769518 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
HRV88_RS22705 (HRV88_22640) 4769515..4770444 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
HRV88_RS22710 (HRV88_22645) 4770488..4770775 - 288 WP_038635893.1 NadS family protein Antitoxin
HRV88_RS22715 (HRV88_22650) 4770776..4771087 - 312 WP_057066653.1 hypothetical protein Toxin
HRV88_RS22720 (HRV88_22655) 4771308..4772237 + 930 WP_235125944.1 alpha/beta hydrolase -
HRV88_RS22725 (HRV88_22660) 4772322..4772633 + 312 WP_048215202.1 type II toxin-antitoxin system HigB family toxin -
HRV88_RS22730 (HRV88_22665) 4772630..4773076 + 447 WP_235125977.1 helix-turn-helix domain-containing protein -
HRV88_RS22735 (HRV88_22670) 4773094..4774035 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
HRV88_RS22740 (HRV88_22675) 4774080..4774517 - 438 WP_003825289.1 D-aminoacyl-tRNA deacylase -
HRV88_RS22745 (HRV88_22680) 4774514..4775386 - 873 WP_008786998.1 virulence factor BrkB family protein -
HRV88_RS22750 (HRV88_22685) 4775380..4775979 - 600 WP_008786997.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-74)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12418.55 Da        Isoelectric Point: 10.0963

>T158760 WP_057066653.1 NZ_CP054129:c4771087-4770776 [Citrobacter portucalensis]
MLFIETEVFTEDVKKLLDDDEYRRLQIFLAIQPDCGDLIQETGGLRKVRWRERGKGKRSGVRIIYFHQIRKSQIRLLLIY
QKGIKDDLTPQEKVLLRMLNERW

Download         Length: 312 bp

>T158760 NZ_CP069809:c1010339-1010070 [Cupriavidus oxalaticus]
ATGGACATCACCTTTGATGTAGCCAAGGACGCCGCCAATCTTTCCAAGCACGGCTTATCGCTACGCGTGGCCGCTCAACT
GGACTGGCCAGCGGTCATGGCGGGCGTTGATACCAGACGGGACTACAGGGAGGTGCGCGAAATCGGCTTTGGCGTGATTG
CCGATCGCCTCTATTGTGTGGTGTTCACTCAGCGTGGGGATGCGATGCACATCATCAGCCTGCGCAAGGCCAACCAACGC
GAGGTACGAAACTATGTCGAGCAAACCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10761.36 Da        Isoelectric Point: 11.1842

>AT158760 WP_038635893.1 NZ_CP054129:c4770775-4770488 [Citrobacter portucalensis]
MDKALFERLTQSMVQMNEIAEGTRQPSRTFHIDAMKIKEIRQSSGLSQTRFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPKHVIQALR

Download         Length: 288 bp

>AT158760 NZ_CP069809:c1010086-1009799 [Cupriavidus oxalaticus]
ATGTCGAGCAAACCTAAGATCGTGATGCCGACCGACGAGGAGGACGCGGCAATCAACCGCGGCATCGCCACCGATCCGGA
CACCTATGAAGTGTCGGCCGATGAAATGATGGCGATGAAGCCTCTTGGCAAACGCGGCCGGGGCCGGCCAAGACTGGGCA
ACACCAAGGAACTCGTCAGCATCCGCTACGATGCCGAAGTTCTGGAAGCTTTCCGTGCGAGCGGAGAAGGCTGGCAGACA
CGAATGAACAGCGCACTCAAAGAGTGGCTTCGCACGCACAGGCCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References